Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells

See allHide authors and affiliations

Science  25 Aug 2017:
Vol. 357, Issue 6353, pp. 806-810
DOI: 10.1126/science.aah5825

Tolerogenic T cells need probiotics

CD4+CD8αα+ double-positive intraepithelial lymphocytes (DP IELs) are a recently discovered class of intestinal T cells believed to take part in a variety of immune responses, including oral tolerance. These cells are absent in germ-free mice, but the mechanisms driving their development are unclear. Cervantes-Barragan et al. found that a particular species of probiotic bacteria, Lactobacillus reuteri, induces DP IELs. This does not occur by stimulating the immune system directly. Instead, L. reuteri generates a specific derivative of dietary tryptophan that promotes differentiation of DP IEL precursors. These findings underscore the delicate interplay between benign bacteria, diet, and gut health.

Science, this issue p. 806

View Full Text

Stay Connected to Science