Research Article

Glia relay differentiation cues to coordinate neuronal development in Drosophila

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Science  01 Sep 2017:
Vol. 357, Issue 6354, pp. 886-891
DOI: 10.1126/science.aan3174

Wiring up the eye

During development, sensory systems must build topographic maps by connecting neurons at different levels within a circuit. Fernandes et al. now open a window into how the Drosophila eye develops these maps (see the Perspective by Isaacman-Beck and Clandinin). The authors show that glial cells that ensheath axons relay cues from photoreceptors to induce the differentiation of the photoreceptor target field—the so-called lamina neurons—in the Drosophila visual system. Thus, glia can play an instructive role in differentiation, helping to direct the spatiotemporal patterning of neurogenesis.

Science, this issue p. 886; see also p. 867

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