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Fabrication of fillable microparticles and other complex 3D microstructures

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Science  15 Sep 2017:
Vol. 357, Issue 6356, pp. 1138-1142
DOI: 10.1126/science.aaf7447

Putting the pieces together

One route to improving the delivery of existing drugs is by encapsulation inside a protective but slowly degrading shell. Such slow-release capsules improve drug availability in vivo, reduce side effects, and allow for more constant dose delivery. McHugh et al. leverage a number of existing fabrication techniques to make tiny (∼400-µm), hollow injectable microparticles that can be filled with fluid containing the therapeutic agent. By adjusting the degradation rate of the microparticle material (in this case, a lactic/glycolic copolymer), the cargo in the internal reservoir can be released at a desired time, ranging from a few days to 2 months.

Science, this issue p. 1138

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