22 September 2017
Vol 357, Issue 6357

About The Cover

Cover image expansion

COVER A 2-week-old piglet whose genome has been engineered to inactivate porcine endogenous retroviruses (PERVs). This animal is from a cell line created using CRISPR technology to inactivate PERVs, the possible transmission of which has hindered effective xenotransplantation. This work addresses safety concerns about crosss-pecies viral transmission and brings us one step closer to reliable pig-to-human organ transplants. See pages 1238 and 1303.
Photo: K. Fan/eGenesis