22 September 2017
Vol 357, Issue 6357
  • Contents

    • This Week in Science

    • Editorial

    • Editors' Choice

    • Departments

    • Products & Materials

      • New Products

        A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.

    • In Brief

    • In Depth

    • Feature

    • Working Life

    • Letters

    • Books et al.

    • Policy Forum

    • Perspectives

    • Review

    • Research Articles

      • Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

        Mice lacking a circular RNA show changes in gene expression in the brain and behavioral abnormalities.

      • Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

        The mitochondrial oxidant stress cascade is linked to lysosomal dysfunction in human, but not mouse, dopaminergic Parkinson’s disease neurons.

      • Observation of a large-scale anisotropy in the arrival directions of cosmic rays above 8 × 1018 eV

        The highest-energy cosmic rays have a dipolar distribution, showing that they originate outside our Galaxy.

    • expression of concern

    • Reports

    • Erratum

About The Cover

Cover image expansion

COVER A 2-week-old piglet whose genome has been engineered to inactivate porcine endogenous retroviruses (PERVs). This animal is from a cell line created using CRISPR technology to inactivate PERVs, the possible transmission of which has hindered effective xenotransplantation. This work addresses safety concerns about crosss-pecies viral transmission and brings us one step closer to reliable pig-to-human organ transplants. See pages 1238 and 1303.
Photo: K. Fan/eGenesis