Report
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
- Dong Niu1,2,*,
- Hong-Jiang Wei3,4,*,
- Lin Lin5,*,
- Haydy George1,*,
- Tao Wang1,*,
- I-Hsiu Lee1,*,
- Hong-Ye Zhao3,
- Yong Wang6,
- Yinan Kan1,
- Ellen Shrock7,
- Emal Lesha1,
- Gang Wang1,
- Yonglun Luo5,
- Yubo Qing3,4,
- Deling Jiao3,4,
- Heng Zhao3,4,
- Xiaoyang Zhou6,
- Shouqi Wang8,
- Hong Wei6,
- Marc Güell1,†,
- George M. Church1,7,9,†,
- Luhan Yang1,†,‡
- 1eGenesis, Cambridge, MA 02139, USA.
- 2College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
- 3State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
- 4College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
- 5Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
- 6Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
- 7Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
- 8Research Institute of Shenzhen Jinxinnong Technology, Shenzhen 518106, China.
- 9Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.
- ↵‡Corresponding author. Email: luhan.yang{at}egenesisbio.com
See allHide authors and affiliations
Science 22 Sep 2017:
Vol. 357, Issue 6357, pp. 1303-1307
DOI: 10.1126/science.aan4187
Vol. 357, Issue 6357, pp. 1303-1307
DOI: 10.1126/science.aan4187
Dong Niu
eGenesis, Cambridge, MA 02139, USA.College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Hong-Jiang Wei
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Lin Lin
Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Haydy George
eGenesis, Cambridge, MA 02139, USA.
Tao Wang
eGenesis, Cambridge, MA 02139, USA.
I-Hsiu Lee
eGenesis, Cambridge, MA 02139, USA.
Hong-Ye Zhao
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
Yong Wang
Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
Yinan Kan
eGenesis, Cambridge, MA 02139, USA.
Ellen Shrock
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Emal Lesha
eGenesis, Cambridge, MA 02139, USA.
Gang Wang
eGenesis, Cambridge, MA 02139, USA.
Yonglun Luo
Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Yubo Qing
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Deling Jiao
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Heng Zhao
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Xiaoyang Zhou
Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
Shouqi Wang
Research Institute of Shenzhen Jinxinnong Technology, Shenzhen 518106, China.
Hong Wei
Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
Marc Güell
eGenesis, Cambridge, MA 02139, USA.
George M. Church
eGenesis, Cambridge, MA 02139, USA.Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.
Luhan Yang
eGenesis, Cambridge, MA 02139, USA.
