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Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
- View ORCID ProfileDong Niu1,2,*,
- View ORCID ProfileHong-Jiang Wei3,4,*,
- View ORCID ProfileLin Lin5,*,
- Haydy George1,*,
- View ORCID ProfileTao Wang1,*,
- View ORCID ProfileI-Hsiu Lee1,*,
- View ORCID ProfileHong-Ye Zhao3,
- Yong Wang6,
- Yinan Kan1,
- Ellen Shrock7,
- View ORCID ProfileEmal Lesha1,
- View ORCID ProfileGang Wang1,
- View ORCID ProfileYonglun Luo5,
- View ORCID ProfileYubo Qing3,4,
- View ORCID ProfileDeling Jiao3,4,
- View ORCID ProfileHeng Zhao3,4,
- Xiaoyang Zhou6,
- View ORCID ProfileShouqi Wang8,
- Hong Wei6,
- View ORCID ProfileMarc Güell1,†,
- View ORCID ProfileGeorge M. Church1,7,9,†,
- View ORCID ProfileLuhan Yang1,†,‡
- 1eGenesis, Cambridge, MA 02139, USA.
- 2College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
- 3State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
- 4College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
- 5Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
- 6Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
- 7Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
- 8Research Institute of Shenzhen Jinxinnong Technology, Shenzhen 518106, China.
- 9Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.
- ↵‡Corresponding author. Email: luhan.yang{at}egenesisbio.com
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Science 22 Sep 2017:
Vol. 357, Issue 6357, pp. 1303-1307
DOI: 10.1126/science.aan4187
Vol. 357, Issue 6357, pp. 1303-1307
DOI: 10.1126/science.aan4187
Dong Niu
1eGenesis, Cambridge, MA 02139, USA.
2College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Hong-Jiang Wei
3State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
4College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Lin Lin
5Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Haydy George
1eGenesis, Cambridge, MA 02139, USA.
Tao Wang
1eGenesis, Cambridge, MA 02139, USA.
I-Hsiu Lee
1eGenesis, Cambridge, MA 02139, USA.
Hong-Ye Zhao
3State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
Yong Wang
6Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
Yinan Kan
1eGenesis, Cambridge, MA 02139, USA.
Ellen Shrock
7Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Emal Lesha
1eGenesis, Cambridge, MA 02139, USA.
Gang Wang
1eGenesis, Cambridge, MA 02139, USA.
Yonglun Luo
5Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Yubo Qing
3State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
4College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Deling Jiao
3State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
4College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Heng Zhao
3State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
4College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Xiaoyang Zhou
6Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
Shouqi Wang
8Research Institute of Shenzhen Jinxinnong Technology, Shenzhen 518106, China.
Hong Wei
6Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
Marc Güell
1eGenesis, Cambridge, MA 02139, USA.
George M. Church
1eGenesis, Cambridge, MA 02139, USA.
7Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
9Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.
Luhan Yang
1eGenesis, Cambridge, MA 02139, USA.
