Research Article

Lattice system of functionally distinct cell types in the neocortex

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Science  03 Nov 2017:
Vol. 358, Issue 6363, pp. 610-615
DOI: 10.1126/science.aam6125

The basic modules of the neocortex

The fundamental organization of excitatory and inhibitory neurons in the neocortex is still poorly understood. Subcerebral projection neurons, a major excitatory cell type in neocortical layer 5, form small cell clusters called microcolumns. Maruoka et al. examined large regions of mouse brain layer 5 and observed that thousands of these microcolumns make up a hexagonal lattice with a regular gridlike spacing. The other major layer 5 excitatory cell class, cortical projection neurons, also form microcolumns that interdigitate with those of the subcerebral projection neurons. Microcolumns received common presynaptic inputs and showed synchronized activity in many cortical areas. These microcolumns developed from nonsister neurons coupled by cell type–specific gap junctions, suggesting that their development is lineage-independent but guided by local electrical transmission.

Science, this issue p. 610

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