ReportMOLECULAR IMAGING

The condensin complex is a mechanochemical motor that translocates along DNA

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Science  03 Nov 2017:
Vol. 358, Issue 6363, pp. 672-676
DOI: 10.1126/science.aan6516

Condensin is a highly processive DNA motor

Condensin is thought to regulate genome architecture by creating DNA loops. Terakawa et al. used single-molecule imaging to show that yeast condensin is a highly processive mechanochemical motor capable of translocating along DNA (see the Perspective by Nasmyth). Their findings elucidate how the rapid ATP hydrolysis–dependent motor activity of condensin provides the driving forces necessary to support three-dimensional chromosome organization and compaction through a loop extrusion mechanism.

Science, this issue p. 672; see also p. 589

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