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Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

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Science  01 Dec 2017:
Vol. 358, Issue 6367, pp. 1182-1187
DOI: 10.1126/science.aap9674

Article Information

vol. 358 no. 6367 1182-1187

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History: 
  • Received for publication September 14, 2017
  • Accepted for publication October 30, 2017

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Author Information

  1. Yong Yao Loh1,*,
  2. Kazunori Nagao1,*,
  3. Andrew J. Hoover2,
  4. David Hesk2,
  5. Nelo R. Rivera2,
  6. Steven L. Colletti3,
  7. Ian W. Davies1,2,
  8. David W. C. MacMillan1,
  1. 1Merck Center for Catalysis at Princeton University, Princeton, NJ 08544, USA.
  2. 2Labeled Compound Synthesis Group, Department of Process R&D, Merck Research Laboratories (MRL), Merck & Co., Inc., Rahway, NJ 07065, USA.
  3. 3Department of Discovery Chemistry, MRL, Merck & Co., Inc., Kenilworth, NJ 07033, USA.
  1. Corresponding author. Email: dmacmill{at}princeton.edu
  1. * These authors contributed equally to this work.

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Nov 2017109528672693
Dec 201764494121792
Jan 20181421201704
Feb 201851172211
Mar 201842767151
Apr 201840363173
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