Report
Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
- View ORCID ProfileV. Gopalakrishnan1,2,*,
- View ORCID ProfileC. N. Spencer2,3,*,
- View ORCID ProfileL. Nezi3,*,
- View ORCID ProfileA. Reuben1,
- View ORCID ProfileM. C. Andrews1,
- View ORCID ProfileT. V. Karpinets3,
- P. A. Prieto1,†,
- View ORCID ProfileD. Vicente1,
- View ORCID ProfileK. Hoffman4,
- View ORCID ProfileS. C. Wei5,
- View ORCID ProfileA. P. Cogdill1,5,
- View ORCID ProfileL. Zhao3,
- View ORCID ProfileC. W. Hudgens6,
- View ORCID ProfileD. S. Hutchinson7,
- T. Manzo3,
- M. Petaccia de Macedo6,‡,
- T. Cotechini8,
- View ORCID ProfileT. Kumar3,
- View ORCID ProfileW. S. Chen9,
- S. M. Reddy10,
- View ORCID ProfileR. Szczepaniak Sloane1,
- J. Galloway-Pena11,
- H. Jiang1,
- P. L. Chen9,§,
- E. J. Shpall12,
- View ORCID ProfileK. Rezvani12,
- A. M. Alousi12,
- R. F. Chemaly11,
- View ORCID ProfileS. Shelburne3,11,
- L. M. Vence5,
- View ORCID ProfileP. C. Okhuysen11,
- V. B. Jensen13,
- View ORCID ProfileA. G. Swennes7,
- View ORCID ProfileF. McAllister14,
- View ORCID ProfileE. Marcelo Riquelme Sanchez14,
- View ORCID ProfileY. Zhang14,
- View ORCID ProfileE. Le Chatelier15,
- L. Zitvogel16,
- View ORCID ProfileN. Pons15,
- View ORCID ProfileJ. L. Austin-Breneman1,||,
- L. E. Haydu1,
- E. M. Burton1,
- View ORCID ProfileJ. M. Gardner1,
- E. Sirmans17,
- J. Hu18,
- View ORCID ProfileA. J. Lazar6,9,
- View ORCID ProfileT. Tsujikawa8,
- View ORCID ProfileA. Diab17,
- View ORCID ProfileH. Tawbi17,
- View ORCID ProfileI. C. Glitza17,
- View ORCID ProfileW. J. Hwu17,
- View ORCID ProfileS. P. Patel17,
- S. E. Woodman17,
- R. N. Amaria17,
- View ORCID ProfileM. A. Davies17,
- View ORCID ProfileJ. E. Gershenwald1,
- View ORCID ProfileP. Hwu17,
- View ORCID ProfileJ. E. Lee1,
- J. Zhang3,
- View ORCID ProfileL. M. Coussens8,
- View ORCID ProfileZ. A. Cooper1,3,¶,
- View ORCID ProfileP. A. Futreal3,
- C. R. Daniel4,2,
- View ORCID ProfileN. J. Ajami7,
- View ORCID ProfileJ. F. Petrosino7,
- View ORCID ProfileM. T. Tetzlaff6,9,
- View ORCID ProfileP. Sharma5,19,
- View ORCID ProfileJ. P. Allison5,
- View ORCID ProfileR. R. Jenq3,#,
- View ORCID ProfileJ. A. Wargo1,3,#,**
- 1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 2Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA.
- 3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 4Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 5Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 6Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 7Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
- 8Department of Cell, Developmental and Cell Biology, Oregon Health and Sciences University, Portland, OR 97239, USA.
- 9Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 10Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 11Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 12Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 13Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 14Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 15Centre de Recherche de Jouy-en-Josas, Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas, France.
- 16Centre d’Investigation Clinique Biothérapie, Institut Gustave-Roussy, 94805 Villejuif Cedex, France.
- 17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 18Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 19Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- ↵**Corresponding author. Email: jwargo{at}mdanderson.org
↵* These authors contributed equally to this work.
↵# These authors contributed equally to this work.
↵† Present address: University of Rochester James P. Wilmot Cancer Center, Rochester, NY 14642, USA.
↵‡ Present address: A.C.Camargo Cancer Center, São Paolo, Brazil.
↵§ Present address: Moffitt Cancer Center, Tampa, FL 33612, USA.
↵|| Present address: Harvard University, Cambridge, MA 02138, USA.
↵¶ Present address: MedImmune, Gaithersburg, MD 20878, USA.
See allHide authors and affiliations
Science 05 Jan 2018:
Vol. 359, Issue 6371, pp. 97-103
DOI: 10.1126/science.aan4236
Vol. 359, Issue 6371, pp. 97-103
DOI: 10.1126/science.aan4236
V. Gopalakrishnan
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
2Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA.
C. N. Spencer
2Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA.
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
L. Nezi
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
A. Reuben
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
M. C. Andrews
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
T. V. Karpinets
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. A. Prieto
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
D. Vicente
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
K. Hoffman
4Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
S. C. Wei
5Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
A. P. Cogdill
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
5Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
L. Zhao
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
C. W. Hudgens
6Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
D. S. Hutchinson
7Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
T. Manzo
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
M. Petaccia de Macedo
6Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
T. Cotechini
8Department of Cell, Developmental and Cell Biology, Oregon Health and Sciences University, Portland, OR 97239, USA.
T. Kumar
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
W. S. Chen
9Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
S. M. Reddy
10Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
R. Szczepaniak Sloane
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. Galloway-Pena
11Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
H. Jiang
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. L. Chen
9Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
E. J. Shpall
12Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
K. Rezvani
12Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
A. M. Alousi
12Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
R. F. Chemaly
11Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
S. Shelburne
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
11Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
L. M. Vence
5Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. C. Okhuysen
11Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
V. B. Jensen
13Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
A. G. Swennes
7Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
F. McAllister
14Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
E. Marcelo Riquelme Sanchez
14Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Y. Zhang
14Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
E. Le Chatelier
15Centre de Recherche de Jouy-en-Josas, Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas, France.
L. Zitvogel
16Centre d’Investigation Clinique Biothérapie, Institut Gustave-Roussy, 94805 Villejuif Cedex, France.
N. Pons
15Centre de Recherche de Jouy-en-Josas, Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas, France.
J. L. Austin-Breneman
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
L. E. Haydu
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
E. M. Burton
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. M. Gardner
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
E. Sirmans
17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. Hu
18Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
A. J. Lazar
6Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
9Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
T. Tsujikawa
8Department of Cell, Developmental and Cell Biology, Oregon Health and Sciences University, Portland, OR 97239, USA.
A. Diab
17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
H. Tawbi
17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
I. C. Glitza
17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
W. J. Hwu
17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
S. P. Patel
17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
S. E. Woodman
17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
R. N. Amaria
17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
M. A. Davies
17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. E. Gershenwald
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. Hwu
17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. E. Lee
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. Zhang
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
L. M. Coussens
8Department of Cell, Developmental and Cell Biology, Oregon Health and Sciences University, Portland, OR 97239, USA.
Z. A. Cooper
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. A. Futreal
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
C. R. Daniel
4Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
2Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA.
N. J. Ajami
7Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
J. F. Petrosino
7Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
M. T. Tetzlaff
6Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
9Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. Sharma
5Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
19Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. P. Allison
5Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
R. R. Jenq
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. A. Wargo
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
