Report
Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
- V. Gopalakrishnan1,2,*,
- C. N. Spencer2,3,*,
- L. Nezi3,*,
- A. Reuben1,
- M. C. Andrews1,
- T. V. Karpinets3,
- P. A. Prieto1,†,
- D. Vicente1,
- K. Hoffman4,
- S. C. Wei5,
- A. P. Cogdill1,5,
- L. Zhao3,
- C. W. Hudgens6,
- D. S. Hutchinson7,
- T. Manzo3,
- M. Petaccia de Macedo6,‡,
- T. Cotechini8,
- T. Kumar3,
- W. S. Chen9,
- S. M. Reddy10,
- R. Szczepaniak Sloane1,
- J. Galloway-Pena11,
- H. Jiang1,
- P. L. Chen9,§,
- E. J. Shpall12,
- K. Rezvani12,
- A. M. Alousi12,
- R. F. Chemaly11,
- S. Shelburne3,11,
- L. M. Vence5,
- P. C. Okhuysen11,
- V. B. Jensen13,
- A. G. Swennes7,
- F. McAllister14,
- E. Marcelo Riquelme Sanchez14,
- Y. Zhang14,
- E. Le Chatelier15,
- L. Zitvogel16,
- N. Pons15,
- J. L. Austin-Breneman1,||,
- L. E. Haydu1,
- E. M. Burton1,
- J. M. Gardner1,
- E. Sirmans17,
- J. Hu18,
- A. J. Lazar6,9,
- T. Tsujikawa8,
- A. Diab17,
- H. Tawbi17,
- I. C. Glitza17,
- W. J. Hwu17,
- S. P. Patel17,
- S. E. Woodman17,
- R. N. Amaria17,
- M. A. Davies17,
- J. E. Gershenwald1,
- P. Hwu17,
- J. E. Lee1,
- J. Zhang3,
- L. M. Coussens8,
- Z. A. Cooper1,3,¶,
- P. A. Futreal3,
- C. R. Daniel4,2,
- N. J. Ajami7,
- J. F. Petrosino7,
- M. T. Tetzlaff6,9,
- P. Sharma5,19,
- J. P. Allison5,
- R. R. Jenq3,#,
- J. A. Wargo1,3,#,**
- 1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 2Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA.
- 3Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 4Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 5Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 6Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 7Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
- 8Department of Cell, Developmental and Cell Biology, Oregon Health and Sciences University, Portland, OR 97239, USA.
- 9Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 10Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 11Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 12Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 13Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 14Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 15Centre de Recherche de Jouy-en-Josas, Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas, France.
- 16Centre d’Investigation Clinique Biothérapie, Institut Gustave-Roussy, 94805 Villejuif Cedex, France.
- 17Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 18Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 19Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- ↵**Corresponding author. Email: jwargo{at}mdanderson.org
↵* These authors contributed equally to this work.
↵# These authors contributed equally to this work.
↵† Present address: University of Rochester James P. Wilmot Cancer Center, Rochester, NY 14642, USA.
↵‡ Present address: A.C.Camargo Cancer Center, São Paolo, Brazil.
↵§ Present address: Moffitt Cancer Center, Tampa, FL 33612, USA.
↵|| Present address: Harvard University, Cambridge, MA 02138, USA.
↵¶ Present address: MedImmune, Gaithersburg, MD 20878, USA.
See allHide authors and affiliations
Science 05 Jan 2018:
Vol. 359, Issue 6371, pp. 97-103
DOI: 10.1126/science.aan4236
Vol. 359, Issue 6371, pp. 97-103
DOI: 10.1126/science.aan4236
V. Gopalakrishnan
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA.
C. N. Spencer
Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA.Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
L. Nezi
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
A. Reuben
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
M. C. Andrews
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
T. V. Karpinets
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. A. Prieto
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
D. Vicente
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
K. Hoffman
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
S. C. Wei
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
A. P. Cogdill
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
L. Zhao
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
C. W. Hudgens
Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
D. S. Hutchinson
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
T. Manzo
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
M. Petaccia de Macedo
Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
T. Cotechini
Department of Cell, Developmental and Cell Biology, Oregon Health and Sciences University, Portland, OR 97239, USA.
T. Kumar
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
W. S. Chen
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
S. M. Reddy
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
R. Szczepaniak Sloane
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. Galloway-Pena
Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
H. Jiang
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. L. Chen
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
E. J. Shpall
Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
K. Rezvani
Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
A. M. Alousi
Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
R. F. Chemaly
Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
S. Shelburne
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
L. M. Vence
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. C. Okhuysen
Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
V. B. Jensen
Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
A. G. Swennes
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
F. McAllister
Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
E. Marcelo Riquelme Sanchez
Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Y. Zhang
Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
E. Le Chatelier
Centre de Recherche de Jouy-en-Josas, Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas, France.
L. Zitvogel
Centre d’Investigation Clinique Biothérapie, Institut Gustave-Roussy, 94805 Villejuif Cedex, France.
N. Pons
Centre de Recherche de Jouy-en-Josas, Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas, France.
J. L. Austin-Breneman
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
L. E. Haydu
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
E. M. Burton
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. M. Gardner
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
E. Sirmans
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. Hu
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
A. J. Lazar
Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
T. Tsujikawa
Department of Cell, Developmental and Cell Biology, Oregon Health and Sciences University, Portland, OR 97239, USA.
A. Diab
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
H. Tawbi
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
I. C. Glitza
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
W. J. Hwu
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
S. P. Patel
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
S. E. Woodman
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
R. N. Amaria
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
M. A. Davies
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. E. Gershenwald
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. Hwu
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. E. Lee
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. Zhang
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
L. M. Coussens
Department of Cell, Developmental and Cell Biology, Oregon Health and Sciences University, Portland, OR 97239, USA.
Z. A. Cooper
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. A. Futreal
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
C. R. Daniel
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA.
N. J. Ajami
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
J. F. Petrosino
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
M. T. Tetzlaff
Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. Sharma
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. P. Allison
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
R. R. Jenq
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J. A. Wargo
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
