Research Article

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

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Science  12 Jan 2018:
Vol. 359, Issue 6372, pp. 191-199
DOI: 10.1126/science.aan4472

Dissecting Plasmodium drug resistance

Malaria is a deadly disease with no effective vaccine. Physicians thus depend on antimalarial drugs to save lives, but such compounds are often rendered ineffective when parasites evolve resistance. Cowell et al. systematically studied patterns of Plasmodium falciparum genome evolution by analyzing the sequences of clones that were resistant to diverse antimalarial compounds across the P. falciparum life cycle (see the Perspective by Carlton). The findings identify hitherto unrecognized drug targets and drug-resistance genes, as well as additional alleles in known drug-resistance genes.

Science, this issue p. 191; see also p. 159

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