Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence

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Science  12 Jan 2018:
Vol. 359, Issue 6372, pp. 210-213
DOI: 10.1126/science.aap8775

Cholera pathogen zaps competition

Many bacterial pathogens inject their hosts with virulence effectors delivered by specialist secretion machines. Vibrio cholerae has a type VI secretion system (T6SS) that can be loaded with protein toxins that target eukaryote host cells or kill competing bacteria. Zhao et al. discovered that mutant V. cholerae lacking a T6SS could not compete against Escherichia coli strains in the mouse gut. In contrast, intact V. cholerae readily gained a foothold in the gut of young mice, pumping up inflammatory immune responses and prompting more violent symptoms.

Science, this issue p. 210

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