Report
Modular radical cross-coupling with sulfones enables access to sp3-rich (fluoro)alkylated scaffolds
- Rohan R. Merchant1,*,
- View ORCID ProfileJacob T. Edwards1,*,
- View ORCID ProfileTian Qin1,*,
- Monika M. Kruszyk1,
- Cheng Bi1,
- Guanda Che2,
- Deng-Hui Bao2,
- Wenhua Qiao2,
- Lijie Sun2,
- Michael R. Collins3,
- View ORCID ProfileOlugbeminiyi O. Fadeyi4,†,
- Gary M. Gallego3,
- James J. Mousseau4,
- View ORCID ProfilePhilippe Nuhant4,
- View ORCID ProfilePhil S. Baran1,‡
- 1Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
- 2Asymchem Life Science (Tianjin), Tianjin Economic-Technological Development Zone, Tianjin 300457, China.
- 3Department of Chemistry, La Jolla Laboratories, Pfizer, 10770 Science Center Drive, San Diego, CA 92121, USA.
- 4Pfizer Medicinal Sciences, Eastern Point Road, Groton, CT 06340, USA.
- ↵‡Corresponding author. Email: pbaran{at}scripps.edu
↵* These authors contributed equally to this work.
↵† Present address: Exploratory Science Center, Merck & Co., Cambridge, MA 02141, USA.
See allHide authors and affiliations
Science 06 Apr 2018:
Vol. 360, Issue 6384, pp. 75-80
DOI: 10.1126/science.aar7335
Vol. 360, Issue 6384, pp. 75-80
DOI: 10.1126/science.aar7335
Rohan R. Merchant
1Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Jacob T. Edwards
1Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Tian Qin
1Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Monika M. Kruszyk
1Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cheng Bi
1Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Guanda Che
2Asymchem Life Science (Tianjin), Tianjin Economic-Technological Development Zone, Tianjin 300457, China.
Deng-Hui Bao
2Asymchem Life Science (Tianjin), Tianjin Economic-Technological Development Zone, Tianjin 300457, China.
Wenhua Qiao
2Asymchem Life Science (Tianjin), Tianjin Economic-Technological Development Zone, Tianjin 300457, China.
Lijie Sun
2Asymchem Life Science (Tianjin), Tianjin Economic-Technological Development Zone, Tianjin 300457, China.
Michael R. Collins
3Department of Chemistry, La Jolla Laboratories, Pfizer, 10770 Science Center Drive, San Diego, CA 92121, USA.
Olugbeminiyi O. Fadeyi
4Pfizer Medicinal Sciences, Eastern Point Road, Groton, CT 06340, USA.
Gary M. Gallego
3Department of Chemistry, La Jolla Laboratories, Pfizer, 10770 Science Center Drive, San Diego, CA 92121, USA.
James J. Mousseau
4Pfizer Medicinal Sciences, Eastern Point Road, Groton, CT 06340, USA.
Philippe Nuhant
4Pfizer Medicinal Sciences, Eastern Point Road, Groton, CT 06340, USA.
Phil S. Baran
1Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
