PerspectiveHypothesis

A unifying concept in vascular health and disease

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Science  20 Apr 2018:
Vol. 360, Issue 6386, pp. 270-271
DOI: 10.1126/science.aat3470

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  • RE: "unifying hypotheses"

    It would do well for Mr. Schwartz et al to review Pauling's orginal theory that collagen breakdown is the initial event in atherogenesis. Vitamin C, a substance critical for collagen maintenance, is synthesized in all but a few mammals. Coinicdentally, it is those mammals that develop the so atherosclerotic plaques with which we are all too familiar. A few necessary aminos (proline and lysine) plus healthy methylation capacity (measured and influenced by homocysteine and MTHFR SNPs) can prevent such breakdown -- which itself is what likely leads to the "invasion" of endothelial tissues by fibrin, lipids, and ultimately calcium. This is the factual "unifying hypothesis". All else – small particle size LDL, high levels of oxidative stress, stealth infections invulnerable endothelium by transient microbacteremia (from permeable intestines and poor dental hygiene), etc., all spell trouble once endothelial collagen polymers breakdown. I have treated many patients for both primary and secondary prevention with the Pauling formula augmented by additional functional medicine principles successfully. Statin drugs may slow the process but at a great process as they are mitochondrial toxins.

    Competing Interests: None declared.

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