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MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

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Science  20 Apr 2018:
Vol. 360, Issue 6386, pp. 336-341
DOI: 10.1126/science.aao1785

Article Information

vol. 360 no. 6386 336-341

PubMed: 
Print ISSN: 
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History: 
  • Received for publication June 22, 2017
  • Resubmitted October 3, 2017
  • Accepted for publication February 27, 2018
  • .

Author Information

  1. Agostinho G. Rocha1,*,
  2. Antonietta Franco1,*,
  3. Andrzej M. Krezel2,
  4. Jeanne M. Rumsey1,
  5. Justin M. Alberti1,
  6. William C. Knight1,
  7. Nikolaos Biris3,
  8. Emmanouil Zacharioudakis3,
  9. James W. Janetka2,
  10. Robert H. Baloh4,
  11. Richard N. Kitsis5,
  12. Daria Mochly-Rosen6,
  13. R. Reid Townsend1,
  14. Evripidis Gavathiotis3,
  15. Gerald W. Dorn II1,
  1. 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  2. 2Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
  3. 3Departments of Biochemistry and Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA.
  4. 4Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  5. 5Departments of Medicine and Cell Biology, Wilf Family Cardiovascular Research Institute, Albert Einstein Cancer Center, and Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY, USA.
  6. 6Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
  1. †Corresponding author. Email: gdorn{at}wustl.edu
  1. * These authors contributed equally to this work.

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