Research Article

Systematic analysis of complex genetic interactions

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Science  20 Apr 2018:
Vol. 360, Issue 6386, eaao1729
DOI: 10.1126/science.aao1729

Article Information

vol. 360 no. 6386

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History: 
  • Received for publication June 25, 2017
  • Accepted for publication February 23, 2018
  • .

Author Information

  1. Elena Kuzmin1,2,*,,
  2. Benjamin VanderSluis3,*,
  3. Wen Wang3,
  4. Guihong Tan1,
  5. Raamesh Deshpande3,
  6. Yiqun Chen1,
  7. Matej Usaj1,
  8. Attila Balint1,4,,
  9. Mojca Mattiazzi Usaj1,
  10. Jolanda van Leeuwen1,
  11. Elizabeth N. Koch3,
  12. Carles Pons3,
  13. Andrius J. Dagilis5,
  14. Michael Pryszlak1,
  15. Jason Zi Yang Wang1,2,
  16. Julia Hanchard1,2,
  17. Margot Riggi6,7,8,9,
  18. Kaicong Xu3,
  19. Hamed Heydari1,2,
  20. Bryan-Joseph San Luis1,
  21. Ermira Shuteriqi1,
  22. Hongwei Zhu1,
  23. Nydia Van Dyk1,
  24. Sara Sharifpoor1,
  25. Michael Costanzo1,
  26. Robbie Loewith6,8,9,
  27. Amy Caudy1,2,
  28. Daniel Bolnick5,
  29. Grant W. Brown1,4,
  30. Brenda J. Andrews1,2,§,
  31. Charles Boone1,2,10,§,
  32. Chad L. Myers3,§
  1. 1The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  2. 2Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  3. 3Department of Computer Science and Engineering, University of Minnesota–Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
  4. 4Department of Biochemistry, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  5. 5Department of Integrative Biology, 1 University Station C0990, University of Texas at Austin, Austin, TX 78712, USA.
  6. 6Department of Molecular Biology, University of Geneva, Geneva 1211, Switzerland.
  7. 7Department of Biochemistry, University of Geneva, 1211 Geneva, Switzerland.
  8. 8iGE3 (Institute of Genetics and Genomics of Geneva), 1211 Geneva, Switzerland.
  9. 9Swiss National Centre for Competence in Research Programme Chemical Biology, 1211 Geneva, Switzerland.
  10. 10RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.
  1. §Corresponding author. Email: chadm{at}umn.edu (C.L.M.); brenda.andrews{at}utoronto.ca (B.J.A.); charlie.boone{at}utoronto.ca (C.B.)
  1. * These authors contributed equally to this work.

  • Present address: Rosalind and Morris Goodman Cancer Research Centre, McGill University, 1160 Avenue des Pins Ouest, Montreal, Quebec H3A 1A3, Canada.

  • Present address: Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

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