Research Article

Self-organization and progenitor targeting generate stable patterns in planarian regeneration

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Science  27 Apr 2018:
Vol. 360, Issue 6387, pp. 404-409
DOI: 10.1126/science.aap8179

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A recipe for regeneration

Unlike humans, planarian flatworms can regenerate certain tissues. During regeneration, existing tissues remodel, and undifferentiated and progenitor cells convert into specialized cell types at specified locations. Atabay et al. examined planarian eye regeneration (see the Perspective by Tanaka). Surgical and transplantation experiments revealed three properties governing regenerative progenitor behavior: cell self-organization, an extrinsic migratory target for progenitors, and a broad progenitor-specification zone. Predictions from this model enabled generation of animals with multiple stable eyes.

Science, this issue p. 404; see also p. 374