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CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

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Science  27 Apr 2018:
Vol. 360, Issue 6387, pp. 436-439
DOI: 10.1126/science.aar6245

Article Information

vol. 360 no. 6387 436-439

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History: 
  • Received for publication November 29, 2017
  • Resubmitted January 22, 2018
  • Accepted for publication February 5, 2018

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Author Information

  1. Janice S. Chen1,*,
  2. Enbo Ma1,*,
  3. Lucas B. Harrington1,*,
  4. Maria Da Costa2,
  5. Xinran Tian3,
  6. Joel M. Palefsky2,
  7. Jennifer A. Doudna1,3,4,5,6,
  1. 1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
  2. 2Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  3. 3Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
  4. 4Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94704, USA.
  5. 5Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
  6. 6Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  1. Corresponding author. Email: doudna{at}berkeley.edu
  1. * These authors contributed equally to this work.

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Article usage: February 2018 to June 2019

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Feb 20181653215192819
Mar 201853837621257
Apr 20181852713732341
May 2018996712522017
Jun 20182737391601
Jul 20182243612433
Aug 201813191037421
Sep 2018974787348
Oct 2018918905361
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Dec 2018887544274
Jan 20191022806330
Feb 20191000741328
Mar 20191343907377
Apr 201913071005344
May 201951591610
Jun 201981245533

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