Heating up suppresses appetite

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Science  18 May 2018:
Vol. 360, Issue 6390, pp. 749-750
DOI: 10.1126/science.360.6390.749-g

Exercise can transiently suppress appetite, and it also makes you hot. Jeong et al. investigated whether loss of appetite is caused by increased body temperature. Hypothalamic neurons that express proopiomelanocortin control food intake. In mice, these neurons express a thermoreceptor called transient receptor potential vanilloid 1 (TRPV1). TRPV1s are activated when exercise increases physiological temperature, suppressing appetite. So, the heat of the moment directly mediates appetite, without invoking canonical nutrient-hormone pathways.

PLOS Biol. 10.1371/journal.pbio.2004399 (2018).

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