An ingestible bacterial-electronic system to monitor gastrointestinal health

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Science  25 May 2018:
Vol. 360, Issue 6391, pp. 915-918
DOI: 10.1126/science.aas9315

Using bugs in the gut to detect blood

Bacteria are environmentally resilient and can be engineered to sense various biomolecules. Mimee et al. combined biosensor bacteria with a miniaturized wireless readout capsule to produce a minimally invasive device capable of in vivo biosensing in harsh, difficult-to-access environments (see the Perspective by Gibson and Burgell). The device successfully measured gastrointestinal bleeding in pigs.

Science, this issue p. 915; see also p. 856