Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

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Science  22 Jun 2018:
Vol. 360, Issue 6395, pp. 1358-1362
DOI: 10.1126/science.aar5304

Surface antibody maturation

Affinity maturation in B cells generates antibodies with increasingly enhanced antigen-binding properties. Imkeller et al. investigated the maturation of human B cells that express protective antibodies against the circumsporozoite protein of the malaria-causing parasite Plasmodium falciparum (PfCSP). The repetitive structure of PfCSP induces mutations in B cells, facilitating direct interactions between two repeat-bound antibodies against PfCSP, which enhance antigen affinity and B cell activation. Such interactions may optimize binding and promote clustering of surface antibodies in general.

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