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Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

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Science  22 Jun 2018:
Vol. 360, Issue 6395, pp. 1358-1362
DOI: 10.1126/science.aar5304

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vol. 360 no. 6395 1358-1362

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History: 
  • Received for publication November 18, 2017
  • Resubmitted March 2, 2018
  • Accepted for publication May 23, 2018

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Author Information

  1. Katharina Imkeller1,2,*,
  2. Stephen W. Scally3,*,
  3. Alexandre Bosch3,
  4. Gemma Pidelaserra Martí1,2,
  5. Giulia Costa4,
  6. Gianna Triller1,
  7. Rajagopal Murugan1,
  8. Valerio Renna5,
  9. Hassan Jumaa5,
  10. Peter G. Kremsner6,
  11. B. Kim Lee Sim7,
  12. Stephen L. Hoffman7,
  13. Benjamin Mordmüller6,
  14. Elena A. Levashina4,
  15. Jean-Philippe Julien3,8,,
  16. Hedda Wardemann1,
  1. 1B Cell Immunology, German Cancer Research Institute, Heidelberg, Germany.
  2. 2Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  3. 3Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  4. 4Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.
  5. 5Institute of Immunology, University Medical Center Ulm, Ulm, Germany.
  6. 6Institute of Tropical Medicine and German Center for Infection Research, Partner Site Tübingen, University of Tübingen, Tübingen, Germany.
  7. 7Sanaria, Rockville, MD, USA.
  8. 8Departments of Biochemistry and Immunology, University of Toronto, Toronto, ON, Canada.
  1. Corresponding author. Email: h.wardemann{at}dkfz.de (H.W.); jean-philippe.julien{at}sickkids.ca (J.-P.J.)
  1. * These authors contributed equally to this work.

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Jun 2018844319032355
Jul 2018588326350
Aug 20182454203
Sep 20180373156
Oct 20180435186
Nov 20180361142
Dec 20180500105
Jan 201910344114
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