Technical Comments

Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

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Science  22 Jun 2018:
Vol. 360, Issue 6395, eaar6910
DOI: 10.1126/science.aar6910

Abstract

Shlezinger et al. (Reports, 8 September 2017, p. 1037) report that the common fungus Aspergillus fumigatus, a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin.

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