Technical Comments

Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

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Science  22 Jun 2018:
Vol. 360, Issue 6395, eaas9457
DOI: 10.1126/science.aas9457

Abstract

Aouacheria et al. question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in Aspergillus fumigatus. Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach.

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