Research Article

A gut-brain neural circuit for nutrient sensory transduction

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Science  21 Sep 2018:
Vol. 361, Issue 6408, eaat5236
DOI: 10.1126/science.aat5236

Dissecting the gut-brain axis

It is generally believed that cells in the gut transduce sensory information through the paracrine action of hormones. Kaelberer et al. found that, in addition to the well-described classical paracrine transduction, enteroendocrine cells also form fast, excitatory synapses with vagal afferents (see the Perspective by Hoffman and Lumpkin). This more direct circuit for gut-brain signaling uses glutamate as a neurotransmitter. Thus, sensory cues that stimulate the gut could potentially be manipulated to influence specific brain functions and behavior, including those linked to food choices.

Science, this issue p. eaat5236; see also p. 1203

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