Hox genes and body segmentation

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Science  28 Sep 2018:
Vol. 361, Issue 6409, pp. 1310-1311
DOI: 10.1126/science.aav0692

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On page 1377 of this issue, He et al. (1) elucidate two long-standing problems in animal evolution: the ancient function of the homeobox (Hox) gene cluster, which has puzzled scientists for decades (2), and the centuries-old debate on the emergence of the segmented animal body.