A mechanism for preventing asymmetric histone segregation onto replicating DNA strands

See allHide authors and affiliations

Science  28 Sep 2018:
Vol. 361, Issue 6409, pp. 1386-1389
DOI: 10.1126/science.aat8849

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

How cells ensure symmetric inheritance

Parental histones with modifications are recycled to newly replicated DNA strands during genome replication, but do the two sister chromatids inherit modified histones equally? Yu et al. and Petryk et al. found in mouse and yeast, respectively, that modified histones are segregated to both DNA daughter strands in a largely symmetric manner (see the Perspective by Ahmad and Henikoff). However, the mechanisms ensuring this symmetric inheritance in yeast and mouse were different. Yeasts use subunits of DNA polymerase to prevent the lagging-strand bias of parental histones, whereas in mouse cells, the replicative helicase MCM2 counters the leading-strand bias.

Science, this issue p. 1386, p. 1389; see also p. 1311