Research Article

Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci

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Science  28 Sep 2018:
Vol. 361, Issue 6409, eaar3146
DOI: 10.1126/science.aar3146

Article Information

vol. 361 no. 6409

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History: 
  • Received for publication October 26, 2017
  • Resubmitted May 7, 2018
  • Accepted for publication August 10, 2018

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Author Information

  1. Vitor Onuchic1,2,3,4,*,,
  2. Eugene Lurie1,3,4,*,
  3. Ivenise Carrero1,3,
  4. Piotr Pawliczek1,3,
  5. Ronak Y. Patel1,3,
  6. Joel Rozowsky5,6,
  7. Timur Galeev5,6,
  8. Zhuoyi Huang1,7,
  9. Robert C. Altshuler4,8,9,
  10. Zhizhuo Zhang8,9,
  11. R. Alan Harris1,3,4,
  12. Cristian Coarfa1,3,4,
  13. Lillian Ashmore1,2,3,
  14. Jessica W. Bertol10,
  15. Walid D. Fakhouri10,
  16. Fuli Yu1,2,7,
  17. Manolis Kellis4,8,9,
  18. Mark Gerstein5,6,
  19. Aleksandar Milosavljevic1,2,3,4,
  1. 1Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.
  2. 2Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, USA.
  3. 3Epigenome Center, Baylor College of Medicine, Houston, TX, USA.
  4. 4NIH Roadmap Epigenomics Project.
  5. 5Program in Computational Biology and Bioinformatics, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
  6. 6Department of Computer Science, Yale University, New Haven, CT, USA.
  7. 7Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
  8. 8Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  9. 9Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA, USA.
  10. 10Center for Craniofacial Research, Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX, USA.
  1. Corresponding author. Email: amilosav{at}bcm.edu
  1. * These authors contributed equally to this work.

  • Present address: Illumina, San Diego, CA, USA.

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