Report

The paraventricular thalamus is a critical thalamic area for wakefulness

See allHide authors and affiliations

Science  26 Oct 2018:
Vol. 362, Issue 6413, pp. 429-434
DOI: 10.1126/science.aat2512

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

A close view of the paraventricular thalamus

The paraventricular thalamus is a relay station connecting brainstem and hypothalamic signals that represent internal states with the limbic forebrain that performs associative functions in emotional contexts. Zhu et al. found that paraventricular thalamic neurons represent multiple salient features of sensory stimuli, including reward, aversiveness, novelty, and surprise. The nucleus thus provides context-dependent salience encoding. The thalamus gates sensory information and contributes to the sleep-wake cycle through its interactions with the cerebral cortex. Ren et al. recorded from neurons in the paraventricular thalamus and observed that both population and single-neuron activity were tightly coupled with wakefulness.

Science, this issue p. 423, p. 429

View Full Text