PerspectiveSTEM CELLS

Changing concepts in hematopoietic stem cells

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Science  23 Nov 2018:
Vol. 362, Issue 6417, pp. 895-896
DOI: 10.1126/science.aat7873

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  • RE: Changing concepts in HSCs
    • Roi Gazit, PI, Ben-Gurion University of the Negev

    Beautiful review that greatly helps the HSC field, and stem cells research in general.

    Authors have made many of the seminal studies that changed the "classical" hematopoietic-TREE into a SHRUB (?) as presented in its schematic Figure. It is very helpful of Ryo Yamamoto, Adam Wilkinson, and Hiromitsu Nakauchi to put such a concise nomenclature and define clearly what we know. Even better- they define some of the cutting-edge questions and set the course for the coming years.

    Probably due to the limited space, this review lacks the embryonic-origin of HSCs, which is a major interest of the field, and for any adult stem cells. Moreover, recent studies suggest bone-marrow independent branches of hematopoietic cells, such as the brain's microglia, and tissue macrophages. By this review definitions, there should be a defined stem-cell for these cells; there is a basic interest and a clinical need to identify these "primitive" and restricted stem cells. To follow one of the intriguing points of this review: are such putative microglia- or macrophage-stem-cell the origin of any separate malignancy?

    The 5-lineages experiments brought amazing discoveries, there are a dozen distinct hematopoietic cell types, and maybe hundreds of sub-types waiting for additional studies.

    A detailed review of blood ontogeny:
    https://www.cell.com/cell-stem-cell/fulltext/S1934-...

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    Competing Interests: None declared.

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