Molecular to organismal chirality is induced by the conserved myosin 1D

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Science  23 Nov 2018:
Vol. 362, Issue 6417, pp. 949-952
DOI: 10.1126/science.aat8642

A single myosin sets chirality at all scales

When viewed externally, most organisms appear symmetric between the left and right sides. However, many organs are left-right asymmetric. Whether macroscopic asymmetries are directly related to molecular-level chirality remains an open question. Working in Drosophila, Lebreton et al. found that the conserved molecular motor myosin 1D induced stereotyped chirality at all biological scales—from F-actin turning in vitro to the organ level and even organismal behavior. Thus, a single conserved myosin can generate de novo nano-to-macroscopic changes in form and direction through chiral interaction with the actin cytoskeleton.

Science, this issue p. 949

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