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Science  23 Nov 2018:
Vol. 362, Issue 6417, pp. 961
DOI: 10.1126/science.362.6417.961

Stem-Cell Cultureware 

Eppendorf's CCCadvanced FN 1 motifs cell cultureware uses synthetic fibronectin (FN)-derived motifs to support cell attachment by mimicking native extracellular matrix (ECM) proteins. The major challenge of induced pluripotent stem cell (iPSC) cultivation is to preserve stem-cell properties until differentiation is induced. To support these properties, an appropriate culture medium and a defined ECM-mimicking growth surface/coating are crucial. Biological coatings commonly used to expand stem cells are inherently complex, nondefined growth surfaces that frequently reduce experimental reproducibility. Poor growth from these coatings is exacerbated by lot-to-lot variations between coating media; the use of undefined growth factors and ECM components known to sustain cell adhesion and pluripotency; and potential pathogen contamination risk during preparation and storage. Eppendorf's cultureware supports long-term expansion of human iPSCs (hiPSCs) over 25 passages, and is also suitable for human mesenchymal stem cells and other ECM-dependent cells. Furthermore, it allows expansion of stem cells in xeno-free and restrictive culture conditions. 

3D-iPSC Matrix

MyEZGel 3D-iPSC, a powerful new tool for in vitro 3D human induced pluripotent stem cell (hiPSC) culture, is a synthetic, xeno-free, hydrogel matrix inspired by muscle and spider-silk proteins. It is proven to overcome basic problems associated with traditional hydrogel-based matrices, such as complicated scaffold synthesis, temperature/pH sensitivity, low harvest/yield, and cellular toxicity from materials used. 3D culture systems for iPSCs are gaining in popularity, as matrix-grown cells have more in vivo–like gene expression; better differentiation potential, proliferation, and cellular function; and are more physiologically relevant in vitro models. Provided as a patented nanofiber solution, a 3D microenvironment can be easily formulated to specific stem-cell growth conditions at room temperature or 37°C. By using MyEZGel, cells can be maintained in a pluripotent state or differentiated for advanced disease modeling and drug discovery research.

Lab Safety Shields

Asynt Lab Safety Shields fit neatly around all major stirrer hotplate brands, providing lab scientists with enhanced safety while maintaining easy access to hotplate controls and good all-around visibility of the reaction or process. Built in robust 5-mm polycarbonate, the new Large Lab Safety Shield offers additional user protection for applications such as heated parallel reactions, especially those requiring user intervention when the fume hood sash is open. The device also shields reactions from the cooling effect of fume hood ventilation. Compactly designed (29.5 cm x 16 cm x 17 cm) to minimize use of valuable fume hood space, Asynt's budget-priced Standard Lab Safety Shield fits neatly around the stirrer hotplate to provide robust, convenient protection from splashes, aerosols, and spills. All Asynt safety shields are resistant to a wide range of laboratory solvents, and temperatures up to 170°C. They can also be optimized to your experimental setup.

Extracellular Matrix Assay

Keratin Orange is an extracellular matrix assay designed to measure α-keratin in mammalian hair samples. α-keratin is a fibrous, structural protein found in all vertebrates in hair, wool, horns, nails, claws, and hooves as well as the stratum corneum of the skin. This simple colorimetric assay is based on the binding of the dye Orange G to α-keratin from digested hair samples. It complements Biocolor's other extracellular matrix assays: the Sircol assay for soluble and insoluble collagen, the Blyscan assay for sulfated glycosaminoglycans, the Fastin assay for elastin, and the Purple-Jelley assay for hyaluronan.  

Shotgun Metagenomic and Strain Sequencing Tests

CoreBiome, a genomics company offering innovative solutions for microbiome discovery, offers USD 99 shotgun metagenomic and strain sequencing tests. These new services provide affordable, high-quality species and gene profiling for the human microbiome, and deep characterization of microbial isolate libraries. BoosterShot, an alternative to amplicon sequencing for large-scale microbiome experimentation, starts at a sequencing depth of 2 million sequences per sample, with a turnaround time of 3 weeks from sample arrival to delivery of a sophisticated, interactive online report, along with raw data. BoosterShot is recommended for human-stool and oral microbiomes, which are low in host-DNA contamination, and are well represented in whole-genome reference databases. The second service, StrainView, is for whole-genome shotgun sequencing of hundreds or thousands of isolated bacterial genomes simultaneously. CoreBiome combines its proprietary, efficient library-preparation protocols with optimal, alignment-based database searches, to deliver genome assemblies for single-isolate samples and visualizations of shared genome content across your strains.

IAA Measurement System

The IAA Physiolyzer is the world's first complete research system for measuring endogenous and exogenous indole-3-acetic acid (IAA). The system uses the noninvasive microtest (NMT) technique to measure not just the concentration of IAA, but also the direction of transport (i.e., influx and efflux) from live samples of any size. IAA flux can be measured from concentrated organelles, single cells, cells, tissue, and small intact organisms, all of which are undamaged by testing. The flux data unfolds on-screen in real time with femtomole sensitivity, and can continue hands-off operation for hours, allowing researchers to see both short- and long-term IAA flux responses to genetic modifications, and to biotic and/or abiotic stimuli. The IAA Physiolyzer is perfect for labs researching development, physiology, signal transduction, and more. 3D flux measurement is also available in advanced versions.

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