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A mechanistic classification of clinical phenotypes in neuroblastoma
- View ORCID ProfileSandra Ackermann1,2,*,
- Maria Cartolano2,3,*,
- View ORCID ProfileBarbara Hero4,
- Anne Welte1,2,
- Yvonne Kahlert1,2,
- Andrea Roderwieser1,2,
- Christoph Bartenhagen1,2,
- Esther Walter1,2,
- Judith Gecht4,
- View ORCID ProfileLaura Kerschke5,
- Ruth Volland4,
- View ORCID ProfileRoopika Menon6,
- View ORCID ProfileJohannes M. Heuckmann6,
- Moritz Gartlgruber7,
- Sabine Hartlieb7,
- Kai-Oliver Henrich7,
- Konstantin Okonechnikov8,
- Janine Altmüller2,9,
- View ORCID ProfilePeter Nürnberg2,9,10,
- Steve Lefever11,
- View ORCID ProfileBram de Wilde11,
- Frederik Sand1,2,
- Fakhera Ikram1,2,12,
- Carolina Rosswog1,2,
- Janina Fischer1,2,
- Jessica Theissen1,4,
- View ORCID ProfileFalk Hertwig1,2,13,14,15,
- Aatur D. Singhi16,
- Thorsten Simon4,
- Wenzel Vogel17,18,
- Sven Perner17,18,
- Barbara Krug19,
- Matthias Schmidt20,
- View ORCID ProfileSven Rahmann21,22,
- Viktor Achter23,
- Ulrich Lang23,24,
- Christian Vokuhl25,
- Monika Ortmann26,
- Reinhard Büttner26,
- View ORCID ProfileAngelika Eggert13,14,15,
- Frank Speleman11,
- Roderick J. O’Sullivan27,
- Roman K. Thomas3,14,26,28,
- Frank Berthold4,*,
- Jo Vandesompele11,*,
- View ORCID ProfileAlexander Schramm29,*,
- View ORCID ProfileFrank Westermann7,*,
- Johannes H. Schulte13,14,15,28,*,
- Martin Peifer2,3,*,
- Matthias Fischer1,2,*,†
- 1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
- 2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
- 3Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany.
- 4Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
- 5Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.
- 6NEO New Oncology GmbH, Cologne, Germany.
- 7Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children′s Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
- 8Division of Pediatric Neurooncology, German Cancer Research Center, and Hopp Children’s Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
- 9Cologne Center for Genomics, University of Cologne, Cologne, Germany.
- 10Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
- 11Center for Medical Genetics, Ghent University, Ghent, Belgium.
- 12Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan.
- 13Department of Pediatric Oncology and Hematology, Charité – Universitätsmedizin Berlin, Berlin, Germany.
- 14German Cancer Consortium (DKTK), Heidelberg, Germany.
- 15Berlin Institute of Health, Berlin, Germany.
- 16Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
- 17Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
- 18Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany.
- 19Department of Diagnostic and Interventional Radiology, University Hospital of Cologne, Cologne, Germany.
- 20Department of Nuclear Medicine, University of Cologne, Cologne, Germany.
- 21Genome Informatics, Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
- 22Computer Science, TU Dortmund, Dortmund, Germany.
- 23Computing Center, University of Cologne, Cologne, Germany.
- 24Department of Informatics, University of Cologne, Cologne, Germany.
- 25Kiel Pediatric Tumor Registry, Department of Pediatric Pathology, University of Kiel, Kiel, Germany.
- 26Department of Pathology, University of Cologne, Cologne, Germany.
- 27Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute (UPCI), Hillman Cancer Center, Pittsburgh, PA, USA.
- 28German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 29Department of Medical Oncology, West German Cancer Center Essen, University of Duisburg-Essen, Essen, Germany.
- ↵†Corresponding author. Email: matthias.fischer{at}uk-koeln.de
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science 07 Dec 2018:
Vol. 362, Issue 6419, pp. 1165-1170
DOI: 10.1126/science.aat6768
Vol. 362, Issue 6419, pp. 1165-1170
DOI: 10.1126/science.aat6768
Sandra Ackermann
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Maria Cartolano
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
3Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany.
Barbara Hero
4Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
Anne Welte
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Yvonne Kahlert
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Andrea Roderwieser
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Christoph Bartenhagen
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Esther Walter
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Judith Gecht
4Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
Laura Kerschke
5Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.
Ruth Volland
4Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
Roopika Menon
6NEO New Oncology GmbH, Cologne, Germany.
Johannes M. Heuckmann
6NEO New Oncology GmbH, Cologne, Germany.
Moritz Gartlgruber
7Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children′s Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
Sabine Hartlieb
7Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children′s Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
Kai-Oliver Henrich
7Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children′s Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
Konstantin Okonechnikov
8Division of Pediatric Neurooncology, German Cancer Research Center, and Hopp Children’s Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
Janine Altmüller
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
9Cologne Center for Genomics, University of Cologne, Cologne, Germany.
Peter Nürnberg
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
9Cologne Center for Genomics, University of Cologne, Cologne, Germany.
10Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Steve Lefever
11Center for Medical Genetics, Ghent University, Ghent, Belgium.
Bram de Wilde
11Center for Medical Genetics, Ghent University, Ghent, Belgium.
Frederik Sand
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Fakhera Ikram
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
12Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan.
Carolina Rosswog
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Janina Fischer
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Jessica Theissen
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
4Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
Falk Hertwig
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
13Department of Pediatric Oncology and Hematology, Charité – Universitätsmedizin Berlin, Berlin, Germany.
14German Cancer Consortium (DKTK), Heidelberg, Germany.
15Berlin Institute of Health, Berlin, Germany.
Aatur D. Singhi
16Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Thorsten Simon
4Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
Wenzel Vogel
17Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
18Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany.
Sven Perner
17Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
18Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany.
Barbara Krug
19Department of Diagnostic and Interventional Radiology, University Hospital of Cologne, Cologne, Germany.
Matthias Schmidt
20Department of Nuclear Medicine, University of Cologne, Cologne, Germany.
Sven Rahmann
21Genome Informatics, Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
22Computer Science, TU Dortmund, Dortmund, Germany.
Viktor Achter
23Computing Center, University of Cologne, Cologne, Germany.
Ulrich Lang
23Computing Center, University of Cologne, Cologne, Germany.
24Department of Informatics, University of Cologne, Cologne, Germany.
Christian Vokuhl
25Kiel Pediatric Tumor Registry, Department of Pediatric Pathology, University of Kiel, Kiel, Germany.
Monika Ortmann
26Department of Pathology, University of Cologne, Cologne, Germany.
Reinhard Büttner
26Department of Pathology, University of Cologne, Cologne, Germany.
Angelika Eggert
13Department of Pediatric Oncology and Hematology, Charité – Universitätsmedizin Berlin, Berlin, Germany.
14German Cancer Consortium (DKTK), Heidelberg, Germany.
15Berlin Institute of Health, Berlin, Germany.
Frank Speleman
11Center for Medical Genetics, Ghent University, Ghent, Belgium.
Roderick J. O’Sullivan
27Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute (UPCI), Hillman Cancer Center, Pittsburgh, PA, USA.
Roman K. Thomas
3Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany.
14German Cancer Consortium (DKTK), Heidelberg, Germany.
26Department of Pathology, University of Cologne, Cologne, Germany.
28German Cancer Research Center (DKFZ), Heidelberg, Germany.
Frank Berthold
4Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
Jo Vandesompele
11Center for Medical Genetics, Ghent University, Ghent, Belgium.
Alexander Schramm
29Department of Medical Oncology, West German Cancer Center Essen, University of Duisburg-Essen, Essen, Germany.
Frank Westermann
7Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children′s Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany.
Johannes H. Schulte
13Department of Pediatric Oncology and Hematology, Charité – Universitätsmedizin Berlin, Berlin, Germany.
14German Cancer Consortium (DKTK), Heidelberg, Germany.
15Berlin Institute of Health, Berlin, Germany.
28German Cancer Research Center (DKFZ), Heidelberg, Germany.
Martin Peifer
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
3Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany.
Matthias Fischer
1Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany.
2Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
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