Research Article

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

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Science  07 Dec 2018:
Vol. 362, Issue 6419, eaat9446
DOI: 10.1126/science.aat9446

Article Information

vol. 362 no. 6419

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History: 
  • Received for publication April 26, 2018
  • Accepted for publication October 18, 2018

Author Information

  1. Yevgeniya Antonova-Koch1,
  2. Stephan Meister1,*,
  3. Matthew Abraham1,
  4. Madeline R. Luth1,
  5. Sabine Ottilie1,
  6. Amanda K. Lukens2,3,
  7. Tomoyo Sakata-Kato3,
  8. Manu Vanaerschot4,
  9. Edward Owen5,
  10. Juan Carlos Jado1,
  11. Steven P. Maher6,7,
  12. Jaeson Calla1,
  13. David Plouffe8,
  14. Yang Zhong8,
  15. Kaisheng Chen8,
  16. Victor Chaumeau9,10,
  17. Amy J. Conway6,7,
  18. Case W. McNamara8,,
  19. Maureen Ibanez8,
  20. Kerstin Gagaring8,,
  21. Fernando Neria Serrano11,
  22. Korina Eribez1,
  23. Cullin McLean Taggard1,
  24. Andrea L. Cheung1,
  25. Christie Lincoln1,
  26. Biniam Ambachew1,
  27. Melanie Rouillier12,
  28. Dionicio Siegel13,
  29. François Nosten9,10,
  30. Dennis E. Kyle6,7,
  31. Francisco-Javier Gamo12,
  32. Yingyao Zhou8,
  33. Manuel Llinás5,14,
  34. David A. Fidock4,
  35. Dyann F. Wirth2,3,
  36. Jeremy Burrows12,
  37. Brice Campo12,
  38. Elizabeth A. Winzeler1,13,
  1. 1School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.
  2. 2Harvard T. H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
  3. 3The Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
  4. 4Division of Infectious Diseases, Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
  5. 5Department of Biochemistry and Molecular Biology and Center for Malaria Research, Pennsylvania State University, University Park, PA 16802, USA.
  6. 6Center for Tropical and Emerging Global Diseases, University of Georgia, 500 D. W. Brooks Drive, Athens, GA 30602, USA.
  7. 7Department of Global Health, University of South Florida, 3720 Spectrum Boulevard, Tampa, FL 33612, USA.
  8. 8The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.
  9. 9Shoklo Malaria Research Unit, Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
  10. 10Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  11. 11Tres Cantos Medicines Development Campus, Malaria DPU, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain.
  12. 12Medicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland.
  13. 13Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA.
  14. 14Department of Chemistry and Center for Infectious Diseases Dynamics, Pennsylvania State University, University Park, PA 16802, USA.
  1. Corresponding author. Email: ewinzeler{at}ucsd.edu
  • * Present address: BioSero, San Diego, CA 92122, USA.

  • Present address: California Institute for Biomedical Research, La Jolla, CA, USA.

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