Research Article

Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk

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Science  14 Dec 2018:
Vol. 362, Issue 6420, eaat4311
DOI: 10.1126/science.aat4311

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  • RE:The reduced activity of Corpus Callosum is typical of degenerative Brain disorders, as Schizophrenia and Alzheimer Disease.
    • Sergio Stagnaro, Director, Quantum Biophysical Semeiotic Research Laboratory
    • Other Contributors:
      • Simone Caramel, President, Società Internazionale di Semeiotica Biofisica Quantistica
      • Marco Marchionni, Segretario, Quantum Biophysical Semeiotic International Society

    The interesting data of this fascinating article are corroborated, from the clinical view-point, by Quantum Biophysical Semeiotic. As a matter of facts, in CVD, T2DM, and Cancer relative Constitution-Dependent, Inherited Real Risks (1-3), both the microcirculatory and neuronal activity of Corpus Callosum is high, starting from birth. Maximum parameter value is bedside observed in T2DM. Technically speaking, in the Corpus Callosum the diastole of peripheral heart , according to C. Allegra, i.e., the duration of dilation of small arteries and arterioles, according to Hammersen, lasts 5 sec. at rest (NN = 6 sec.).On the contrary, in schizophrenia, AD, and all other degenerative brain disorders, such a activity is reduced: diastole Duration of small arteries and arterioles = 5 sec. (4,5)
    1) Sergio Stagnaro and Simone Caramel. The Inherited Real Risk of Coronary Artery Disease, Nature PG., EJCN, European Journal Clinical Nutrition, Nature PG., [Medline]
    2) Sergio Stagnaro and Simone Caramel (2013). Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention. Frontiers in Endocrinology. Front Endocrinol (Lausanne). 2013; 4: 17.
    Published online 2013 Feb 26. doi: [10.3389/fendo.2013.00017] [MEDLINE]
    3) Sergio Stagnaro and Simone Caramel. BRCA-1 a...

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    Competing Interests: None declared.
  • RE: Bedside Assessing Corpus Callosum Activity plays a central Role in the fight against growing epidemics, as CVD, T2DM, Brain degenerative Disorders, and Cancer.
    • Sergio Stagnaro, Director, Quantum Biophysical Semeiotic Research Laboratory

    CVD, T2DM, Brain degenerative disorders, and Cancer are today's growing epidemics, especially due to the late diagnosis. As T2DM is concerned, first problem still open is to recognize diabetics so far without proper diagnosis, in order to avoid the series of complications that arise decades before the clinical diabetic symptomatology decades before the clinical diabetic symptomatology. FDA Commissioner Scott Gottlieb, MD, said: "Diabetes affects nearly 30 million Americans. Access to affordable insulin is literally a matter of life and death". Aurobindo would say this is a true and false statement. Why do we all, including FDA, not radically solve the real problem underlying the diabetic growing epidemic? Let's start talking about Pre-Primary and Primary Prevention of T2DM, based on Diabetic and Dislipidemic-Dependent, Inherited Real Risk, bedside diagnosed from birth with a stethoscope, and removed by inexpensive Reconstructing Mitochodrial Quantum Therapy. The till now open problem in the traditional Accademic Medicine is the early clinical diagnosis of T2DM from the First of its Five Stages., as well as of CVD and Cancer, strting from birth, namely from the related Inherited Real Risks.
    Recently, a new and original reliable clinical method for diagnosing the above mentioned disorders has been added to a flurry of quantum biophysical semeiotic methods that have existed for twenty years.
    The Corpus Callosum is the part of the brain th...

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    Competing Interests: None declared.

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