Research Article

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

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Science  14 Dec 2018:
Vol. 362, Issue 6420, eaat8127
DOI: 10.1126/science.aat8127

Article Information

vol. 362 no. 6420

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History: 
  • Received for publication April 10, 2018
  • Accepted for publication November 13, 2018

Author Information

  1. Michael J. Gandal1,2,3,4,*,
  2. Pan Zhang5,
  3. Evi Hadjimichael6,7,8,9,
  4. Rebecca L. Walker2,3,4,
  5. Chao Chen10,11,
  6. Shuang Liu12,
  7. Hyejung Won2,3,4,13,14,
  8. Harm van Bakel7,
  9. Merina Varghese9,15,
  10. Yongjun Wang16,
  11. Annie W. Shieh17,
  12. Jillian Haney1,2,3,
  13. Sepideh Parhami1,2,3,
  14. Judson Belmont6,7,8,9,
  15. Minsoo Kim1,4,
  16. Patricia Moran Losada5,
  17. Zenab Khan7,
  18. Justyna Mleczko18,
  19. Yan Xia10,17,
  20. Rujia Dai10,17,
  21. Daifeng Wang19,
  22. Yucheng T. Yang12,
  23. Min Xu12,
  24. Kenneth Fish18,
  25. Patrick R. Hof9,15, 20,
  26. Jonathan Warrell12,
  27. Dominic Fitzgerald21,
  28. Kevin White21,22,23,
  29. Andrew E. Jaffe24,25,
  30. PsychENCODE Consortium,
  31. Mette A. Peters26,
  32. Mark Gerstein12,
  33. Chunyu Liu10,17,27,*,
  34. Lilia M. Iakoucheva5,*,
  35. Dalila Pinto6,7,8,9,*,
  36. Daniel H. Geschwind1,2,3,4,*
  1. *Corresponding author. Email: mgandal{at}mednet.ucla.edu (M.J.G.); liuch{at}upstate.edu (C.L.); lilyak{at}ucsd.edu (L.M.I.); dalila.pinto{at}mssm.edu (D.P.); dhg{at}mednet.ucla.edu (D.H.G.)
    1. 1Department of Psychiatry, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles E. Young Drive South, Los Angeles, CA 90095, USA.
    2. 2Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
    3. 3Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles E. Young Drive South, Los Angeles, CA 90095, USA.
    4. 4Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
    5. 5Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
    6. 6Department of Psychiatry, and Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
    7. 7Department of Genetics and Genomic Sciences, and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
    8. 8The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
    9. 9Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
    10. 10The School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
    11. 11National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, Hunan 410078, China.
    12. 12Program in Computational Biology and Bioinformatics, Departments of Molecular Biophysics and Biochemistry, Computer Science, and Statistics & Data Science, Yale University, New Haven, CT 06520, USA.
    13. 13Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
    14. 14UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
    15. 15Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
    16. 16The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
    17. 17Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
    18. 18Departments of Medicine and Cardiology, Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
    19. 19Department of Biomedical Informatics, Stony Brook University, Stony Brook, NY 11794, USA.
    20. 20Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
    21. 21Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
    22. 22Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA.
    23. 23Tempus Labs, Chicago, IL 60654, USA.
    24. 24Lieber Institute for Brain Development, Baltimore, MD 21205, USA.
    25. 25Departments of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
    26. 26CNS Data Coordination Group, Sage Bionetworks, Seattle, WA 98109, USA.
    27. 27School of Psychology, Shaanxi Normal University, Xian, Shaanxi 710000, China.
    • PsychENCODE Consortium authors and affiliations are listed in the supplementary materials.

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