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Science  21 Dec 2018:
Vol. 362, Issue 6421, pp. 1429
DOI: 10.1126/science.362.6421.1429

Polymer and Protein Molecular Weight Analyzer

The BI-MwA Molecular Weight Analyzer from Testa Analytical Solutions is a high-performance tool for studying synthetic and natural polymers in solution as well as investigating protein aggregation, oligomerization, and complex formation. Employing a 30-mW, 660-nm diode laser, the BI-MwA uses seven angles to determine the intensity of scattered light as a function of angle and polymer concentration. Using this information, the system software can quickly produce Zimm, Berry, and Debye plots from which weight average molecular weight (Mw), radius of gyration (Rg), and second viral coefficient (A2) data are calculated. The BI-MwA can be used in batch or flow mode, as part of a multidetector gel permeation chromatography/size-exclusion chromatography (GPC/SEC) system, or for following the kinetics of polymerization using the tunable diode laser absorption spectroscopy (TDLAS) technique.

Automated Rotary Vial Washer

SP PennTech's RW-500 rotary vial washer is a small, automated system designed for low-to-medium output pharmaceutical and biotech applications. This washer has only two moving parts inside the washing chamber, and does not use needles, minimizing the chance of glassware damage and the possibility of a U.S. Food and Drug Administration (FDA) 483 notice for a product containing unintended particulates. Suitable for washing the full range of pharmaceutical vials from 2 mL–100 mL, the RW-500 combines effective vial washing with automatic tray loading, enabling outputs of up to 100 vials/min. Each vial format has a human–machine interface (HMI)-selected "recipe" with specific settings for variables such as spraying time and indexing time. Water for injection may optionally be recycled, filtered, and reused for early wash stages, and intermittent spraying further reduces water consumption. 

CRISPR/Cas9 Gene Editing Kits

AMS Biotechnology (AMSBIO) offers CRISPR kits for almost any project type, including knockouts, knockins, point mutations, gene replacements, humanizations, tagging, and many more. CRISPR/Cas9 is a simple, efficient genome editing tool that allows for specific genome disruption and replacement, resulting in high specificity and low cell toxicity. The custom-designed CRISPR Complete Kit consists of CRISPR RNA (crRNA), transactivating crRNA (tracrRNA), Cas9 nuclease protein, and donor construct. The donor construct may be provided as oligonucleotide or plasmid, depending on project needs. AMSBIO also offers a comprehensive selection of CRISPR/Cas9 products for genome engineering—including Cas9 and guide RNA (gRNA) delivery systems in a flexible range of formats, homologous recombination donor vectors, and AAVS1 safe harbor targeting. This includes all-in-one Cas9/gRNA vectors, vectors for multiplex gRNA delivery, Cas9 messenger RNA and protein for transfection, and quantitative PCR primers and antibodies for Cas9 detection.

Custom High-Pressure Parallel Reactor

The Asynt High-Pressure Parallel Reactor can be custom configured to optimally suit applications including homogeneous and heterogeneous catalysis, hydrogenation, carbonylation, corrosion testing, parallel synthesis, and screening. Typically constructed from durable 316 stainless steel, this reactor is an affordable, compact unit that can be used to screen 10 mL × 30 mL reactions at pressures up to 200 bar and temperatures of 320°C. It can be used with a hotplate stirrer or customized for more rapid heating and/or multiple temperature zones. Several options are available, ranging from facilities for internal cell measurement, to sealed sample/additions valves, condenser jackets, electrical heating options, liquid charging systems, gas supply/mixing systems, air-driven stirrers, purged heating chambers, and more. Drawing upon skilled United Kingdom craftsmen, Asynt can also build these reactors from alternative materials, such as Hastelloy, Inconel, titanium, and alloy steels, allowing for greater heat capacity and use with particularly corrosive or caustic chemicals.

hPSC Genetic Analysis Kit

Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells, acquire recurrent genetic abnormalities during prolonged culturing. These karyotypic abnormalities can alter the behavior of stem cells, jeopardizing the validity of a disease model, drug screen, or cell therapy. The hPSC Genetic Analysis Kit from STEMCELL Technologies contains all required components to detect over 70% of the most common karyotypic abnormalities reported in hPSC cultures. This quantitative PCR–based kit enables screening of multiple human stem cell lines in a rapid, cost-effective manner. It uses double-quenched probes, which give superior performance over single-quenched probes, and detects the copy number of the minimal critical regions of commonly mutated genetic loci with high specificity and sensitivity. By addressing an unmet need in the field, it empowers researchers to confirm stem-cell culture quality and have confidence in their data. 

Lyophilizer

The Ultra Lyophilizer from SP Scientific is a compact, free-standing freeze-drying system that can process bulk products, vials of all shapes and sizes, and large numbers of microplates. With the Ultra, you can specify up to 2.13 m2 of useable shelf area in a footprint of only 1.13 m2. The highly polished 316 stainless-steel product chamber, shelves, and smooth-walled condenser chamber ensure that best-processing conditions can be easily maintained and that the freeze dryer gives many years of trouble-free operation. Up to 15 shelves can be specified, and interspacing can be simply rearranged in most models. With shelf temperatures as low as –70°C and condenser temperatures down to –85°C, the Ultra supports a wide range of applications. Easy-defrost condensers enable fast turnaround between runs. A choice of condenser capacities of 35 L or 50 L allows you to select a high shelf-surface-to-condenser-surface ratio, which is most suitable for freeze-drying products requiring a very large amount of shelf area but containing less solvent, as is the case with many diagnostic kits and tissue-banking applications. 

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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