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Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut

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Science  11 Jan 2019:
Vol. 363, Issue 6423, pp. 181-187
DOI: 10.1126/science.aau5238

Article Information

vol. 363 no. 6423 181-187

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History: 
  • Received for publication June 19, 2018
  • Accepted for publication December 3, 2018

Author Information

  1. Xiaofang Jiang1,2,*,
  2. A. Brantley Hall2,3,*,
  3. Timothy D. Arthur2,
  4. Damian R. Plichta2,3,
  5. Christian T. Covington2,3,
  6. Mathilde Poyet1,2,4,
  7. Jessica Crothers5,
  8. Peter L. Moses6,
  9. Andrew C. Tolonen2,3,
  10. Hera Vlamakis2,3,
  11. Eric J. Alm1,2,4,,
  12. Ramnik J. Xavier1,2,3,7,
  1. 1Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  2. 2Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  3. 3Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  4. 4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  5. 5Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT 05401, USA.
  6. 6Division of Gastroenterology and Hepatology, University of Vermont, Burlington, VT 05401, USA.
  7. 7Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  1. Corresponding author. Email: xavier{at}molbio.mgh.harvard.edu (R.J.X.); ejalm{at}mit.edu (E.J.A.)
  1. * These authors contributed equally to this work.

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