Cell-autonomous clock of astrocytes drives circadian behavior in mammals

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Science  11 Jan 2019:
Vol. 363, Issue 6423, pp. 187-192
DOI: 10.1126/science.aat4104

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  • RE: Astrocytes are Involved with Sleep because of DHEA Levels

    I suggest the findings of Brancaccio, et al., may be explained by dehydroepiandrosterone (DHEA) levels. A significant connection of astrocytes and DHEA exists in the literature. It is my hypothesis that DHEA reduction and stimulation is the function of sleep.

    Very briefly, it is my hypothesis that the function of sleep is to produce dehydroepiandrosterone (DHEA) which stimulates consciousness ( ). My mechanism suggests that the light-dark cycle is involved in stimulating DHEA. This requires melatonin production during the dark phase which then results in the production of DHEA. Melatonin triggers prolactin production which is a direct and specific stimulator of DHEA. As DHEA is literally used during the day, melatonin increases at sleep. During sleep the melatonin - prolactin cycle increases until sufficient levels of DHEA are produced to induce awakening and consciousness during the day. The function of sleep / circadian rhythm is production of DHEA.

    I suggest the connection of astrocytes with "the master clock in the brain" is production of dehydroepiandrosterone.

    Competing Interests: None declared.

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