Research Article

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission

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Science  11 Jan 2019:
Vol. 363, Issue 6423, eaao4827
DOI: 10.1126/science.aao4827

Article Information

vol. 363 no. 6423

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  • Received for publication July 31, 2017
  • Resubmitted September 30, 2018
  • Accepted for publication November 14, 2018

Author Information

  1. Heather C. Rice1,2,
  2. Daniel de Malmazet3,4,
  3. An Schreurs5,
  4. Samuel Frere6,
  5. Inge Van Molle7,
  6. Alexander N. Volkov7,8,
  7. Eline Creemers1,2,
  8. Irena Vertkin6,
  9. Julie Nys1,2,
  10. Fanomezana M. Ranaivoson9,*,
  11. Davide Comoletti9,10,,
  12. Jeffrey N. Savas11,
  13. Han Remaut7,
  14. Detlef Balschun5,
  15. Keimpe D. Wierda1,2,
  16. Inna Slutsky6,
  17. Karl Farrow3,4,12,13,
  18. Bart De Strooper1,2,14,,
  19. Joris de Wit1,2,
  1. 1VIB Center for Brain & Disease Research, Leuven, Belgium.
  2. 2Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  3. 3Neuro-Electronics Research Flanders, Leuven, Belgium.
  4. 4Department of Biology, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  5. 5Brain & Cognition, KU Leuven, Leuven, Belgium.
  6. 6Department of Physiology and Pharmacology, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  7. 7VIB–VUB Structural Biology Research Center, Brussels, Belgium.
  8. 8Jean Jeener NMR Centre, VUB, Brussels, Belgium.
  9. 9Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, NJ, USA.
  10. 10Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, NJ, USA.
  11. 11Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  12. 12VIB, Leuven, Belgium.
  13. 13imec, Leuven, Belgium.
  14. 14UK–Dementia Research Institute at University College London, UK.
  1. Corresponding author. Email: bart.destrooper{at} (B.D.S.); joris.dewit{at} (J.d.W.)
  • * Present address: Structural Motility, Institut Curie, PSL Research University, CNRS, UMR 144, Paris, France.

  • Present address: School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.


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