Research Article

Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution

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Science  18 Jan 2019:
Vol. 363, Issue 6424, eaau8302
DOI: 10.1126/science.aau8302

Article Information

vol. 363 no. 6424

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History: 
  • Received for publication July 19, 2018
  • Accepted for publication November 30, 2018
  • .

Author Information

  1. Ruixuan Gao1,2,3,*,
  2. Shoh M. Asano1,2,*,,
  3. Srigokul Upadhyayula3,4,5,6,*,
  4. Igor Pisarev3,
  5. Daniel E. Milkie3,
  6. Tsung-Li Liu3,,
  7. Ved Singh3,§,
  8. Austin Graves3,,
  9. Grace H. Huynh1,#,
  10. Yongxin Zhao1,**,
  11. John Bogovic3,
  12. Jennifer Colonell3,
  13. Carolyn M. Ott3,
  14. Christopher Zugates7,
  15. Susan Tappan8,
  16. Alfredo Rodriguez8,
  17. Kishore R. Mosaliganti9,
  18. Shu-Hsien Sheu3,
  19. H. Amalia Pasolli3,
  20. Song Pang3,
  21. C. Shan Xu3,
  22. Sean G. Megason9,
  23. Harald Hess3,
  24. Jennifer Lippincott-Schwartz3,
  25. Adam Hantman3,
  26. Gerald M. Rubin3,
  27. Tom Kirchhausen3,4,5,6,
  28. Stephan Saalfeld3,
  29. Yoshinori Aso3,
  30. Edward S. Boyden1,2,10,11,12,13,††,
  31. Eric Betzig3,14,15,16,17,18,††
  1. 1MIT Media Lab, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  2. 2McGovern Institute for Brain Research, MIT, Cambridge, MA 02139, USA.
  3. 3Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
  4. 4Department of Cell Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
  5. 5Program in Cellular and Molecular Medicine, Boston Children’s Hospital, 200 Longwood Avenue, Boston, MA 02115, USA.
  6. 6Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
  7. 7arivis AG, 1875 Connecticut Avenue NW, 10th floor, Washington, DC 20009, USA.
  8. 8MBF Bioscience, 185 Allen Brook Lane, Suite 101, Williston, VT 05495, USA.
  9. 9Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
  10. 10Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
  11. 11MIT Center for Neurobiological Engineering, MIT, Cambridge, MA 02139, USA.
  12. 12Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
  13. 13Koch Institute, MIT, Cambridge, MA 02139, USA.
  14. 14Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
  15. 15Department of Physics, University of California, Berkeley, CA 94720, USA.
  16. 16Howard Hughes Medical Institute, Berkeley, CA 94720, USA.
  17. 17Helen Wills Neuroscience Institute, Berkeley, CA 94720, USA.
  18. 18Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  1. ††Corresponding author. Email: esb{at}media.mit.edu (E.S.B.); betzige{at}janelia.hhmi.org (E.B.)
  1. * These authors contributed equally to this work.

  • Present address: Internal Medicine Research Unit, Pfizer, Cambridge, MA 02139, USA.

  • Present address: Vertex Pharmaceuticals, 3215 Merryfield Row, San Diego, CA 92121, USA.

  • § Present address: Intel, 2501 Northwest 229th Avenue, Hillsboro, OR 97124, USA.

  • Present address: Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

  • # Present address: Microsoft Research Lab, 14820 NE 36th Street, Redmond, WA 98052, USA.

  • ** Present address: Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15143, USA.

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