An ingestible self-orienting system for oral delivery of macromolecules

Alex Abramson; Ester Caffarel-Salvador; Minsoo Khang; David Dellal; David Silverstein; Yuan Gao; Morten Revsgaard Frederiksen; Andreas Vegge; František Hubálek; Jorrit J. Water; Anders V. Friderichsen; Johannes Fels; Rikke Kaae Kirk; Cody Cleveland; Joy Collins; Siddartha Tamang; Alison Hayward; Tomas Landh; Stephen T. Buckley; Niclas Roxhed; Ulrik Rahbek; Robert Langer; Giovanni Traverso

doi:10.1126/science.aau2277

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An ingestible self-orienting system for oral delivery of macromolecules

View ORCID ProfileAlex Abramson ¹,
View ORCID ProfileEster Caffarel-Salvador¹,²,
View ORCID ProfileMinsoo Khang ¹,
View ORCID ProfileDavid Dellal ²,
View ORCID ProfileDavid Silverstein ¹,
View ORCID ProfileYuan Gao¹,
View ORCID ProfileMorten Revsgaard Frederiksen³,
Andreas Vegge³,
View ORCID ProfileFrantišek Hubálek³,
View ORCID ProfileJorrit J. Water³,
View ORCID ProfileAnders V. Friderichsen³,
View ORCID ProfileJohannes Fels³,
Rikke Kaae Kirk³,
View ORCID ProfileCody Cleveland¹,³,
View ORCID ProfileJoy Collins¹,
Siddartha Tamang¹,
View ORCID ProfileAlison Hayward¹,⁴,
Tomas Landh³,
View ORCID ProfileStephen T. Buckley³,
View ORCID ProfileNiclas Roxhed ¹,⁵,
View ORCID ProfileUlrik Rahbek³,
View ORCID ProfileRobert Langer ¹,²,⁶,*,
View ORCID ProfileGiovanni Traverso ¹,⁷,⁸,*

¹Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
²Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
³Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
⁴Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁵Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden.
⁶Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁷Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁸Division of Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

↵*Corresponding author. Email: rlanger{at}mit.edu (R.L.); ctraverso{at}bwh.harvard.edu (G.T.)

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Science 08 Feb 2019:
Vol. 363, Issue 6427, pp. 611-615
DOI: 10.1126/science.aau2277

Alex Abramson

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Ester Caffarel-Salvador

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Minsoo Khang

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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David Dellal

2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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David Silverstein

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Yuan Gao

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Morten Revsgaard Frederiksen

3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Andreas Vegge

3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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František Hubálek

3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Jorrit J. Water

3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Anders V. Friderichsen

3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Johannes Fels

3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Rikke Kaae Kirk

3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Cody Cleveland

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Joy Collins

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Siddartha Tamang

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Alison Hayward

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Tomas Landh

3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Stephen T. Buckley

3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Niclas Roxhed

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden.

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Ulrik Rahbek

3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Robert Langer

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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For correspondence: rlanger@mit.edu ctraverso@bwh.harvard.edu

Giovanni Traverso

1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

7Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

8Division of Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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ORCID record for Giovanni Traverso
For correspondence: rlanger@mit.edu ctraverso@bwh.harvard.edu

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