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An ingestible self-orienting system for oral delivery of macromolecules
- View ORCID ProfileAlex Abramson1,
- View ORCID ProfileEster Caffarel-Salvador1,2,
- View ORCID ProfileMinsoo Khang1,
- View ORCID ProfileDavid Dellal2,
- View ORCID ProfileDavid Silverstein1,
- View ORCID ProfileYuan Gao1,
- View ORCID ProfileMorten Revsgaard Frederiksen3,
- Andreas Vegge3,
- View ORCID ProfileFrantišek Hubálek3,
- View ORCID ProfileJorrit J. Water3,
- View ORCID ProfileAnders V. Friderichsen3,
- View ORCID ProfileJohannes Fels3,
- Rikke Kaae Kirk3,
- View ORCID ProfileCody Cleveland1,3,
- View ORCID ProfileJoy Collins1,
- Siddartha Tamang1,
- View ORCID ProfileAlison Hayward1,4,
- Tomas Landh3,
- View ORCID ProfileStephen T. Buckley3,
- View ORCID ProfileNiclas Roxhed1,5,
- View ORCID ProfileUlrik Rahbek3,
- View ORCID ProfileRobert Langer1,2,6,*,
- View ORCID ProfileGiovanni Traverso1,7,8,*
- 1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
- 4Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 5Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden.
- 6Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 7Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 8Division of Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- ↵*Corresponding author. Email: rlanger{at}mit.edu (R.L.); ctraverso{at}bwh.harvard.edu (G.T.)
See allHide authors and affiliations
Science 08 Feb 2019:
Vol. 363, Issue 6427, pp. 611-615
DOI: 10.1126/science.aau2277
Vol. 363, Issue 6427, pp. 611-615
DOI: 10.1126/science.aau2277
Alex Abramson
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ester Caffarel-Salvador
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Minsoo Khang
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
David Dellal
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
David Silverstein
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Yuan Gao
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Morten Revsgaard Frederiksen
3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
Andreas Vegge
3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
František Hubálek
3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
Jorrit J. Water
3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
Anders V. Friderichsen
3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
Johannes Fels
3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
Rikke Kaae Kirk
3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
Cody Cleveland
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
Joy Collins
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Siddartha Tamang
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Alison Hayward
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tomas Landh
3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
Stephen T. Buckley
3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
Niclas Roxhed
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
5Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden.
Ulrik Rahbek
3Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
Robert Langer
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
6Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Giovanni Traverso
1Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
8Division of Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
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