An ingestible self-orienting system for oral delivery of macromolecules

Alex Abramson; Ester Caffarel-Salvador; Minsoo Khang; David Dellal; David Silverstein; Yuan Gao; Morten Revsgaard Frederiksen; Andreas Vegge; František Hubálek; Jorrit J. Water; Anders V. Friderichsen; Johannes Fels; Rikke Kaae Kirk; Cody Cleveland; Joy Collins; Siddartha Tamang; Alison Hayward; Tomas Landh; Stephen T. Buckley; Niclas Roxhed; Ulrik Rahbek; Robert Langer; Giovanni Traverso

doi:10.1126/science.aau2277

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An ingestible self-orienting system for oral delivery of macromolecules

Alex Abramson ¹,
Ester Caffarel-Salvador¹,²,
Minsoo Khang ¹,
David Dellal ²,
David Silverstein ¹,
Yuan Gao¹,
Morten Revsgaard Frederiksen³,
Andreas Vegge³,
František Hubálek³,
Jorrit J. Water³,
Anders V. Friderichsen³,
Johannes Fels³,
Rikke Kaae Kirk³,
Cody Cleveland¹,³,
Joy Collins¹,
Siddartha Tamang¹,
Alison Hayward¹,⁴,
Tomas Landh³,
Stephen T. Buckley³,
Niclas Roxhed ¹,⁵,
Ulrik Rahbek³,
Robert Langer ¹,²,⁶,*,
Giovanni Traverso ¹,⁷,⁸,*

¹Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
²Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
³Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
⁴Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁵Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden.
⁶Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁷Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁸Division of Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

↵*Corresponding author. Email: rlanger{at}mit.edu (R.L.); ctraverso{at}bwh.harvard.edu (G.T.)

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Science 08 Feb 2019:
Vol. 363, Issue 6427, pp. 611-615
DOI: 10.1126/science.aau2277

Alex Abramson

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Ester Caffarel-Salvador

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Minsoo Khang

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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David Dellal

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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David Silverstein

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Yuan Gao

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Morten Revsgaard Frederiksen

Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Andreas Vegge

Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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František Hubálek

Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Jorrit J. Water

Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Anders V. Friderichsen

Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Johannes Fels

Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Rikke Kaae Kirk

Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Cody Cleveland

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Joy Collins

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Siddartha Tamang

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Alison Hayward

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Tomas Landh

Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Stephen T. Buckley

Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Niclas Roxhed

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Ulrik Rahbek

Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.

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Robert Langer

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For correspondence: rlanger@mit.edu ctraverso@bwh.harvard.edu

Giovanni Traverso

Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Division of Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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For correspondence: rlanger@mit.edu ctraverso@bwh.harvard.edu

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