In DepthNeuroscience

Unexpected drug emerges for stroke recovery

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Science  22 Feb 2019:
Vol. 363, Issue 6429, pp. 805
DOI: 10.1126/science.363.6429.805

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In the hours after a stroke, the clot-busting treatment tissue plasminogen activator can limit damage to the brain. But once that damage is done, no drugs are known to promote recovery. New research suggests such a therapy could come from an unlikely target: a cellular protein called CCR5 that allows HIV to infect cells. Scientists found that in mice, disabling CCR5 helps surviving neurons make new connections, and that people who carry a CCR5 mutation may recover better from a stroke. They hope to launch a clinical trial this year that gives stroke patients an HIV drug that blocks CCR5.