Books et al.Gerontology

In search of an aging antidote

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Science  22 Feb 2019:
Vol. 363, Issue 6429, pp. 822
DOI: 10.1126/science.aaw2246

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What causes aging, and how do we intervene? In Borrowed Time, Sue Armstrong describes proposed hallmarks of aging—which include accumulation of cellular damage, loss of stem cell function, cellular senescence, and others—and makes a cogent case for the role of each in driving age-associated dysfunction. Along the way, she describes the origins and development of the aging research field.