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A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

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Science  22 Feb 2019:
Vol. 363, Issue 6429, pp. 875-880
DOI: 10.1126/science.aav0569

Article Information

vol. 363 no. 6429 875-880

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History: 
  • Received for publication August 9, 2018
  • Accepted for publication January 28, 2019

Author Information

  1. Marcus Schewe1,*,,
  2. Han Sun2,*,
  3. Ümit Mert1,
  4. Alexandra Mackenzie3,4,5,
  5. Ashley C. W. Pike3,
  6. Friederike Schulz1,
  7. Cristina Constantin6,7,
  8. Kirsty S. Vowinkel8,
  9. Linus J. Conrad4,5,
  10. Aytug K. Kiper8,
  11. Wendy Gonzalez9,10,
  12. Marianne Musinszki1,
  13. Marie Tegtmeier1,
  14. David C. Pryde11,,
  15. Hassane Belabed12,
  16. Marc Nazare12,
  17. Bert L. de Groot13,
  18. Niels Decher8,
  19. Bernd Fakler6,7,
  20. Elisabeth P. Carpenter3,4,
  21. Stephen J. Tucker4,5,
  22. Thomas Baukrowitz1,
  1. 1Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.
  2. 2Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Structural Biology, 13125 Berlin, Germany.
  3. 3Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
  4. 4OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.
  5. 5Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK.
  6. 6Institute of Physiology II, Albert-Ludwigs University of Freiburg, 79104 Freiburg, Germany.
  7. 7Centers for Biological Signaling Studies CIBSS and BIOSS, 79104 Freiburg, Germany.
  8. 8Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany.
  9. 9Centro de Bioinformatica y Simulacion Molecular, Universidad de Talca, 3465548 Talca, Chile.
  10. 10Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, 3465548 Talca, Chile.
  11. 11Pfizer Worldwide Medicinal Chemistry, Neuroscience and Pain Research Unit, Portway Building, Granta Park, Great Abington, Cambridgeshire CB21 6GS, UK.
  12. 12Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Medicinal Chemistry, 13125 Berlin, Germany.
  13. 13Computational Biomolecular Dynamics Group, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
  1. Corresponding author. Email: m.schewe{at}physiologie.uni-kiel.de (M.S.); t.baukrowitz{at}physiologie.uni-kiel.de (T.B.)
  1. * These authors contributed equally to this work.

  • Present address: Curadev Pharma Ltd., Sandwich Kent, UK.

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