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Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

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Science  01 Mar 2019:
Vol. 363, Issue 6430, pp. 993-998
DOI: 10.1126/science.aat7186

Article Information

vol. 363 no. 6430 993-998

PubMed: 
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History: 
  • Received for publication March 30, 2018
  • Resubmitted September 16, 2018
  • Accepted for publication February 8, 2019

Author Information

  1. Joep Grootjans1,2,*,
  2. Niklas Krupka1,3,*,
  3. Shuhei Hosomi1,4,*,
  4. Juan D. Matute1,5,
  5. Thomas Hanley1,
  6. Svetlana Saveljeva6,
  7. Thomas Gensollen1,
  8. Jarom Heijmans7,
  9. Hai Li3,
  10. Julien P. Limenitakis3,
  11. Stephanie C. Ganal-Vonarburg3,
  12. Shengbao Suo8,
  13. Adrienne M. Luoma9,
  14. Yosuke Shimodaira10,
  15. Jinzhi Duan1,
  16. David Q. Shih10,
  17. Margaret E. Conner11,
  18. Jonathan N. Glickman12,
  19. Gwenny M. Fuhler13,
  20. Noah W. Palm14,
  21. Marcel R. de Zoete15,
  22. C. Janneke van der Woude13,
  23. Guo-Cheng Yuan8,
  24. Kai W. Wucherpfennig9,
  25. Stephan R. Targan10,
  26. Philip Rosenstiel16,
  27. Richard A. Flavell14,17,
  28. Kathy D. McCoy18,
  29. Andrew J. Macpherson3,
  30. Arthur Kaser6,
  31. Richard S. Blumberg1,
  1. 1Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
  2. 2Amsterdam University Medical Center, University of Amsterdam, Department of Gastroenterology and Hepatology and Tygat Institute for Liver and Intestinal Research, Meibergdreef 9, Amsterdam, Netherlands.
  3. 3Maurice Müller Laboratories (DBMR), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland.
  4. 4Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.
  5. 5Division of Neonatology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  6. 6Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
  7. 7Amsterdam University Medical Center, University of Amsterdam, Department of Internal Medicine, Tygat Institute for Liver and Intestinal Research, Meibergdreef 9, Amsterdam, Netherlands.
  8. 8Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  9. 9Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
  10. 10F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  11. 11Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
  12. 12Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  13. 13Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  14. 14Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA.
  15. 15Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
  16. 16Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Rosalind-Franklin-Str. 12, 24105 Kiel, Germany.
  17. 17Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06519, USA.
  18. 18Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.
  1. Corresponding author. Email: rblumberg{at}bwh.harvard.edu
  1. * These authors contributed equally to this work.

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