Essays on Science and SocietyREGENERATIVE MEDICINE

From poor prognosis to promising treatment

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Science  08 Mar 2019:
Vol. 363, Issue 6431, pp. 1051
DOI: 10.1126/science.aaw3609


Over the past several decades, evidence has accumulated that stromal cells—the nonmutated cells that surround malignant cancer cells—are not mere bystanders in tumorigenesis. Instead, they play a crucial role in cancer progression. We now know that metastatic cancer cells must reprogram the tumor stroma, or tumor microenvironment (TME), before they can metastasize (13). They must also contend with the immune system that strives to limit tumor spreading. If the road to metastasis is full of intense obstacles, how can this disease be so devastating?

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