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AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate

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Science  08 Mar 2019:
Vol. 363, Issue 6431, pp. 1085-1088
DOI: 10.1126/science.aav1749

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vol. 363 no. 6431 1085-1088

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History: 
  • Received for publication August 21, 2018
  • Accepted for publication January 22, 2019

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Author Information

  1. Qilin Gu1,
  2. Xiaojie Yang1,*,
  3. Jie Lv1,2,*,
  4. Jiaxiong Zhang1,3,*,
  5. Bo Xia1,2,
  6. Jun-dae Kim1,
  7. Ruoyu Wang4,5,
  8. Feng Xiong4,
  9. Shu Meng1,
  10. Thomas P. Clements6,
  11. Bhavna Tandon6,
  12. Daniel S. Wagner6,
  13. Miguel F. Diaz7,
  14. Pamela L. Wenzel7,
  15. Yury I. Miller8,
  16. David Traver9,
  17. John P. Cooke1,10,11,
  18. Wenbo Li4,5,
  19. Leonard I. Zon12,
  20. Kaifu Chen1,2,10,11,,
  21. Yongping Bai3,,
  22. Longhou Fang1,10,11,13,
  1. 1Center for Cardiovascular Regeneration, Houston Methodist, 6550 Fannin Street, Houston, TX 77030, USA.
  2. 2Center for Bioinformatics and Computational Biology, Department of Cardiovascular Sciences, Houston Methodist, 6550 Fannin Street, Houston, TX 77030, USA.
  3. 3Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
  4. 4Department of Biochemistry and Molecular Biology, UTHealth McGovern Medical School, University of Texas MD Anderson Cancer Center and UTHealth Houston, Houston, TX 77030, USA.
  5. 5Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center and UTHealth Houston, Houston, TX 77030, USA.
  6. 6Department of BioSciences, Rice University, Houston, TX 77005, USA.
  7. 7Children’s Regenerative Medicine Program, Department of Pediatric Surgery, Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  8. 8Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  9. 9Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  10. 10Houston Methodist Institute for Academic Medicine, Houston Methodist Research Institute, Houston Methodist, 6550 Fannin Street, Houston, TX 77030, USA.
  11. 11Department of Cardiothoracic Surgeries, Weill Cornell Medical College, Cornell University, Ithaca, NY 10065, USA.
  12. 12Stem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
  13. 13Department of Obstetrics and Gynecology, Houston Methodist, 6550 Fannin Street, Houston, TX 77030, USA.
  1. Corresponding author. Email: lhfang{at}houstonmethodist.org (L.F.); kchen2{at}houstonmethodist.org (K.C.); baiyongping{at}csu.edu.cn (Y.B.)
  1. * These authors contributed equally to this work.

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