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Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase

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Science  08 Mar 2019:
Vol. 363, Issue 6431, pp. 1088-1092
DOI: 10.1126/science.aau3903

Article Information

vol. 363 no. 6431 1088-1092

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History: 
  • Received for publication June 5, 2018
  • Accepted for publication February 7, 2019

Author Information

  1. Gerta Hoxhaj1,
  2. Issam Ben-Sahra2,
  3. Sophie E. Lockwood1,
  4. Rebecca C. Timson1,
  5. Vanessa Byles1,
  6. Graham T. Henning1,
  7. Peng Gao3,
  8. Laura M. Selfors4,
  9. John M. Asara5,
  10. Brendan D. Manning1,*
  1. 1Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  2. 2Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  3. 3Metabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
  4. 4Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
  5. 5Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  1. *Corresponding author. Email: bmanning{at}hsph.harvard.edu

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