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A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

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Science  08 Mar 2019:
Vol. 363, Issue 6431, pp. 1098-1103
DOI: 10.1126/science.aau5721

Article Information

vol. 363 no. 6431 1098-1103

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History: 
  • Received for publication June 29, 2018
  • Accepted for publication January 10, 2019

Author Information

  1. William Y. C. Huang1,*,
  2. Steven Alvarez2,,
  3. Yasushi Kondo1,3,4,,
  4. Young Kwang Lee1,
  5. Jean K. Chung1,
  6. Hiu Yue Monatrice Lam1,
  7. Kabir H. Biswas5,,
  8. John Kuriyan1,3,4,6,7,
  9. Jay T. Groves1,4,7,§
  1. 1Department of Chemistry, University of California, Berkeley, CA 94720, USA.
  2. 2Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA.
  3. 3Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
  4. 4California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA.
  5. 5Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.
  6. 6Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
  7. 7Divisions of Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  1. §Corresponding author. Email: jtgroves{at}lbl.gov
  1. These authors contributed equally to this work.

  • * Present address: Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.

  • Present address: School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.

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