Research Article

Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis

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Science  08 Mar 2019:
Vol. 363, Issue 6431, eaat4042
DOI: 10.1126/science.aat4042

Article Information

vol. 363 no. 6431

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  • Received for publication February 22, 2018
  • Resubmitted October 11, 2018
  • Accepted for publication January 28, 2019
  • .

Author Information

  1. Mark S. Ladinsky1,*,
  2. Leandro P. Araujo2,*,
  3. Xiao Zhang3,
  4. John Veltri4,
  5. Marta Galan-Diez2,,,
  6. Salima Soualhi2,,§,
  7. Carolyn Lee2,
  8. Koichiro Irie2,5,
  9. Elisha Y. Pinker2,
  10. Seiko Narushima6,
  11. Sheila Bandyopadhyay3,
  12. Manabu Nagayama6,7,
  13. Wael Elhenawy8,
  14. Brian K. Coombes8,
  15. Ronaldo P. Ferraris4,
  16. Kenya Honda6,9,
  17. Iliyan D. Iliev10,
  18. Nan Gao3,
  19. Pamela J. Bjorkman1,,
  20. Ivaylo I. Ivanov2,
  1. 1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  2. 2Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  3. 3Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.
  4. 4Department of Pharmacology, Physiology and Neurosciences, Rutgers University, Newark, NJ 07103, USA.
  5. 5Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
  6. 6RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan.
  7. 7Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi 329-0498, Japan.
  8. 8Department of Biochemistry & Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
  9. 9Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  10. 10Department of Microbiology and Immunology and The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY 10065, USA.
  1. Corresponding author. Email: bjorkman{at} (P.J.B.); ii2137{at} (I.I.I.)
  1. * These authors contributed equally to this work.

  2. These authors contributed equally to this work.

  • Present address: Department of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

  • § Present address: Division of Gastroenterology, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.


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